5445-26-1

Basic information

• Product Name: Ethyl 4-nitrophenylacetate
• Synonyms: ETHYL 4-NITROPHENYLACETATE;ETHYL P-NITROPHENYLACETATE;4-NITROPHENYLACETIC ACID ETHYL ESTER;ALPHA-ETHYL-P-NITRO PHENYL ACETIC ACID;P-NITROPHENYLACETIC ACID ETHYL ESTER;4-nitro-benzeneaceticaciethylester;Acetic acid, (p-nitrophenyl)-, ethyl ester;Acetic acid, 2-(4-nitrophenyl)-, ethyl ester
• CAS NO: 5445-26-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• EINECS: 226-646-5
• Product Categories: Acids and Derivatives;Aromatic Esters;Aromatics;Miscellaneous Reagents
• Mol File: 5445-26-1.mol
• Article Data: 40

Chemical Properties

• Melting Point: 61-65 °C
• Boiling Point: 196 °C / 20mmHg
• Flash Point: 144.11 °C
• Appearance: light yellow crystalline powder
• Density: 1.2944 (rough estimate)
• Vapor Pressure: 0.000283mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DMSO
• BRN: 2053241
• CAS DataBase Reference: Ethyl 4-nitrophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-nitrophenylacetate(5445-26-1)
• EPA Substance Registry System: Ethyl 4-nitrophenylacetate(5445-26-1)

Safety Data

• Safety Statements: 24/25
• TSCA: T
• Hazardous Substances Data: 5445-26-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

Uses

Ethyl (4-Nitrophenyl)acetate (cas# 5445-26-1) is a compound useful in organic synthesis.

InChI:InChI=1/C10H11NO4/c1-2-15-10(12)7-8-3-5-9(6-4-8)11(13)14/h3-6H,2,7H2,1H3

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 107-13-1 acrylonitrile 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 1416159-19-7 (1E)-1-ethoxy-2-(4-nitrophenyl)-5-(trimethylsilyl)pent-1-en-4-yn-3-one 
• 618-39-3 benzamidin 
• 1357356-72-9 1-(4-nitrophenyl)-4-(trimethylsilyl)but-3-yn-2-one 
• 100-00-5 4-chlorobenzonitrile 
• 105-53-3 diethyl malonate 
• 104-03-0 4-nitrobenzeneacetic acid 
• 103-82-2 phenylacetic acid 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 2555-25-1 3-(4-nitrophenyl)coumarin 
• 179173-63-8 1-[[1-[3-Ethoxycarbonyl-3-(4-nitrophenyl)propionyl]-4-piperidyl]methyl]-1H-2-methylimidazo[4,5-c]pyridine 
• 179174-10-8 3-ethoxycarbonyl-3-(4-nitrophenyl)propionic acid 
• 637356-51-5 3-azido-2-(4-nitrophenyl)propan-1-ol 
• 91748-03-7 1,3-dihydroxy-2-(4-nitrophenyl)propane 
• 148582-46-1 ethyl (3-isopropyl-4-nitrophenyl)acetate 
• 924309-82-0 (3-isopropyl-4-[N'-(2-methylphenyl)ureido]phenyl)acetic acid 
• 924309-78-4 ethyl (4-amino-3-isopropylphenyl)acetate 
• 10565-13-6 diethyl 2-(4-Nitrophenyl)malonate 
• 198152-82-8 2-(4-nitro-phenyl)-succinic acid 4-tert-butyl ester 1-ethyl ester 

Relevant articles and documents

Immunomodulator

The invention provides an immunomodulator, and belongs to the field of medical chemistry. The immunomodulator is a compound represented by formula I, or a stereoisomer, or a salt, or a solvate, or a prodrug, or a metabolite thereof. The compound disclosed by the invention shows good IL-17A inhibitory activity, can be used for preparing an IL-17A inhibitor, is used for treating diseases with abnormal IL-17A activity, and the invention provides a new medicinal possibility for clinically treating diseases related to abnormal IL-17A activity.

Immunomodulator

The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a formula I or a stereoisomer thereof in preparation of medicines for inhibiting IL-17A, and provides a new choice for clinically screening and/or preparing medicines for treating diseases related to IL-17A activity.

FUNCTIONALISED AMINE DERIVATIVES AS IL-17 MODULATORS

A series of functionalised amine derivatives of formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.