7709-13-9

Basic information

• Product Name: 4-AMino-2-chloro-1,3,5-triazine
• Synonyms: 4-AMino-2-chloro-1,3,5-triazine;4-chloro-1,3,5-triazin-2-amine
• CAS NO: 7709-13-9
• Molecular Formula: C₃H₃ClN₄
• Molecular Weight: 130.53572
• Product Categories: Amines;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 7709-13-9.mol

Chemical Properties

• Boiling Point: 383.3°C at 760 mmHg
• Flash Point: 185.6°C
• Appearance: /
• Density: 1.566g/cm³
• Vapor Pressure: 4.45E-06mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Dichloromethane, Methanol
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: 4-AMino-2-chloro-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-2-chloro-1,3,5-triazine(7709-13-9)
• EPA Substance Registry System: 4-AMino-2-chloro-1,3,5-triazine(7709-13-9)

Safety Data

• Hazardous Substances Data: 7709-13-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H3ClN4/c4-2-6-1-7-3(5)8-2/h1H,(H2,5,6,7,8)

Upstream product

• 1912-24-9 6-chloro-N-ethyl-N'-isopropyl-1,3,5-triazine-2,4-diamine 
• 2831-66-5 2,4-dichloro-1,3,5-triazine 

Downstream Products

• 1122-73-2 2-amino-4-methoxy-1,3,5-triazine 
• 931-86-2 5-azacytosine 
• 1167546-85-1 4-{[2-(3-methoxyphenyl)-8-methylquinolin-3-yl]methoxy}-1,3,5-triazin-2-amine 

Relevant articles and documents

SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY

In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

INHIBITORS OF CELLULAR METABOLIC PROCESSES

The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

The invention relates to novel heteroaryl and heterocycle compounds and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3k and for treating inflammatory and autoimmune disorders diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITION AND METHODS THEREOF

Disclosed are novel heteroaryl and heterocycle compounds of formula I-1, I-2 or I-3 and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune diseases and cancer.

NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS

Provided are novel heteroaryl and heterocycle compounds of formula (I-1), (I-2) or (I-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of PI3K and for treating inflammatory and autoimmune disorders diseases and cancer.

CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION

Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

4-Amino-2-chloro-1,3,5-triazine: A New Metabolite of Atrazine by a Soil Bacterium

The degradation of herbicide atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) by a soil bacterium is reported.The bacterium involved is a species of Nocardia, which utilizes the atrazine as the sole source of carbon and nitrogen.A new metabolite, 4-amino-2-chloro-1,3,5-triazine, of the degradation of atrazine in the presence of glucose has been identified.The results further substantiated that atrazine can be degraded by soil microorganisms and indicated that deamination can also occur, as well as dealkylation. 4-Amino-2-chloro-1,3,5-triazine did not show phytotoxic activity to oat (Avena sativa L.), demonstrating that deamination insures detoxification.