1122-73-2Relevant academic research and scientific papers
INHIBITORS OF CELLULAR METABOLIC PROCESSES
-
Page/Page column 180-181, (2018/03/25)
The invention provides inhibitor compounds of MAT2A that are useful as therapeutic agents for treating malignancies wherein the compounds have the general formula (I) : wherein ring A, ring B, ring C and, R1 are as described herein.
KONETICS OF THE REACTION OF GUANYL-O-METHYLISOUREA HYDROCHLORIDE WITH DIMETHYLFORMAMIDE DIMETHYLACETAL
Kavalek, Jaromir,Panchartek, Josef,Potesil, Tomas,Sterba, Vojeslav
, p. 1964 - 1971 (2007/10/02)
The reaction of guanyl-O-methylisourea hydrochloride (IV) with dimethylformamide dimethylacetal (V) proceeds in two steps.The first step consists in the reaction of the imidoester with the imidatonium ion formed in a fast pre-equilibrium to give a conjugated system with the absorption maximum at 278 nm.The subsequent slower step consists in the cyclization to 2-amino-4-methoxy-1,3,5-triazine (VI).The rate of the first step is directly proportional to the concentrations of both hydrochloride IV and acetal V.Both the steps involve base catalysis.Mechanism of the whole reaction is suggested on the basis of the kinetic results.
PREPARATION OF SUBSTITUTED 5-PYRIMIDINECARBONITRILES AND 1,3,5-TRIAZINES FROM ALKYL N-CYANOIMIDATES
Perez, Miguel A.,Soto, Jose L
, p. 463 - 468 (2007/10/02)
Sodium methoxide induced the cyclization of alkyl N-cyanoimidates 1 with propanedinitrile affording the 5-pyrimidinecarbonitriles 2.The reaction of 1 with methyl cyanoaetate led to the methyl 3-propenoates 7 and the 2,4-dioxo-5-pyrimidinecarbonitrile 8.An analogous cyclization of 1 with cyanamide yielded the 1,3,5-triazines 10.
4-Amino-2-chloro-1,3,5-triazine: A New Metabolite of Atrazine by a Soil Bacterium
Giardina, M. C.,Giardi, M. T.,Filacchioni, G.
, p. 2067 - 2072 (2007/10/02)
The degradation of herbicide atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) by a soil bacterium is reported.The bacterium involved is a species of Nocardia, which utilizes the atrazine as the sole source of carbon and nitrogen.A new metabolite, 4-amino-2-chloro-1,3,5-triazine, of the degradation of atrazine in the presence of glucose has been identified.The results further substantiated that atrazine can be degraded by soil microorganisms and indicated that deamination can also occur, as well as dealkylation. 4-Amino-2-chloro-1,3,5-triazine did not show phytotoxic activity to oat (Avena sativa L.), demonstrating that deamination insures detoxification.
