77378-54-2

Basic information

• Product Name: 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene
• Synonyms: 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene;Benzene, 2-(bromomethyl)-1-methyl-3-nitro-
• CAS NO: 77378-54-2
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 77378-54-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene(77378-54-2)
• EPA Substance Registry System: 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene(77378-54-2)

Safety Data

• Hazardous Substances Data: 77378-54-2(Hazardous Substances Data)

Usage

General Description

2-(BromoMethyl)-1-Methyl-3-nitrobenzene, also known as α-Bromo-α-methyl-m-nitrotoluene, is a chemical compound with the molecular formula C8H8BrNO2. It is a derivative of toluene and contains a bromine and a nitro group as well as a methyl group on the benzene ring. 2-(BroMoMethyl)-1-Methyl-3-nitrobenzene is commonly used in organic synthesis and can be used to produce various other chemicals. It is a yellow crystalline solid at room temperature and is slightly soluble in water. 2-(BromoMethyl)-1-Methyl-3-nitrobenzene is considered to be toxic and should be handled with caution.

Upstream product

• 66126-16-7 1,2-bis(bromomethyl)-3-nitrobenzene 
• 83-41-0 2,3-dimethylnitrobenzene 
• 66232-57-3 2-methyl-6-nitrobenzoyl chloride 
• 54915-41-2 2-(hydroxymethyl)-3-methyl-1-nitrobenzene 

Downstream Products

• 872323-59-6 diethyl (acetylamino)(2-methyl-6-nitrobenzyl)malonate 

Relevant articles and documents

METHOD FOR PRODUCING 2-(HALOGENOMETHYL)-3-METHYLNITROBENZENE

Position-1 halogen can be selectively reduced by reacting a compound represented by formula (3): [wherein X represents a chlorine atom, a bromine atom, or an iodine atom] with halogen in the presence of a heterogeneous transition metal catalyst to produce 2-(halogenomethyl)-1-methyl-3-nitrobenzene represented by formula (1): [wherein the symbol is as defined above].

TETRAZOLINONE COMPOUND AND USE THEREOF

The compound represented by formula (1): wherein R4 and R5 each represents a hydrogen atom, a halogen atom, or a C1-C3 alkyl group; R6 represents a C1-C4 alkyl group, a C3-C6 cycloalkyl group, or the like; R7, R8, and R9 each represents a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group, or the like; R13 represents a C1-C3 alkyl group, or the like; and Q represents a phenyl group, or the like; has an excellent control effect on pests.

A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction

We describe a generalized approach to stereocontrolled synthesis of substituted cyclic hydroxamic acids (3-amino-1-hydroxy-3,4-dihydroquinolinones) by selective reduction of substituted 2-nitrophenylalanine substrates. Compounds in this series have antibacterial properties and have also recently been reported as KAT II inhibitors. The key nitrophenyl alanine intermediates are prepared enantioselectively in excellent yield by phase transfer catalyzed alkylation of the corresponding nitrobenzyl bromides. The scope and limitations of the reductive cyclization transformation have been explored with attention to the effects of substitution pattern and electronics on reaction efficiency and byproduct formation. In addition, a novel activated trifluoroethyl ester cyclization strategy has been developed as an alternate approach to the most sterically demanding systems in this series.