66232-57-3

Basic information

• Product Name: 2-METHYL-6-NITROBENZOYL CHLORIDE
• Synonyms: 6-NITRO-O-TOLUOYL CHLORIDE;2-METHYL-6-NITROBENZOYL CHLORIDE;Benzoyl chloride, 2-methyl-6-nitro- (9CI)
• CAS NO: 66232-57-3
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.59
• Product Categories: ACIDHALIDE
• Mol File: 66232-57-3.mol
• Article Data: 18

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 311.9°C at 760 mmHg
• Flash Point: 142.4°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 0.000548mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 2-METHYL-6-NITROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-6-NITROBENZOYL CHLORIDE(66232-57-3)
• EPA Substance Registry System: 2-METHYL-6-NITROBENZOYL CHLORIDE(66232-57-3)

Safety Data

• Statements: 34
• Safety Statements: 36/37/39-45
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 66232-57-3(Hazardous Substances Data)

Usage

General Description

2-methyl-6-nitrobenzoyl chloride is a chemical compound with the molecular formula C8H6ClNO3. It is a derivative of benzoyl chloride, with a methyl group and a nitro group attached to the benzene ring. 2-methyl-6-nitrobenzoyl chloride is an important intermediate in the synthesis of various biologically active compounds, pharmaceuticals, and agrochemicals. It is commonly used in organic synthesis as a reagent for the introduction of the 6-nitrobenzoyl group into other molecules. 2-methyl-6-nitrobenzoyl chloride is a yellowish-brown liquid at room temperature and has a strong, pungent odor. It is a reactive compound and should be handled with caution in laboratory settings.

InChI:InChI=1/C8H6ClNO3/c1-5-3-2-4-6(10(12)13)7(5)8(9)11/h2-4H,1H3

Upstream product

• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 1885-76-3 2-cyano-3-nitrotoluene 
• 40637-78-3 2-methyl-6-nitro-benzoic acid amide 

Downstream Products

• 59383-41-4 2-Methyl-6-nitro-benzoic acid prop-2-ynyl ester 
• 59383-43-6 allyl 2-methyl-6-nitrobenzoate 
• 59383-39-0 2-Methyl-6-nitro-benzoic acid 2-chloro-ethyl ester 
• 54915-41-2 2-(hydroxymethyl)-3-methyl-1-nitrobenzene 
• 100230-80-6 (2S)-N-(6-methyl-2-nitrobenzoyl)proline 
• 160891-87-2 N-(2-methyl-6-nitrobenzoyl)-2-(2,5-dimethylphenyl)ethylamine 
• 160891-86-1 N-(2-methyl-6-nitrobenzoyl)-2-phenylethylamine 
• 99057-92-8 6-Nitro-2-methyl-benzoesaeure-<2-brom-aethylester> 
• 107096-52-6 2-methyl-6-nitrobenzaldehyde 
• 77378-54-2 1-(bromomethyl)-6-methyl-2-nitrobenzene 
• 146667-90-5 6-methyl-2-nitrostyrene 
• 393078-47-2 1-(2-methyl-6-nitrophenyl)-1,2-ethanediol 
• 393078-43-8 2,2-dimethyl-4-(2-methyl-6-nitrophenyl)-1,3-dioxolane 
• 107096-56-0 4-formyl-2,1-benzisoxazole 

Relevant articles and documents

COMPOUNDS, COMPOSITIONALS, AND METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

In an aspect, the disclosure provides for compounds (II), compositions, and methods of administering the compounds and compositions to a patient in need thereof. In another aspect, the disclosure relates to compounds and compositions for treating cancer,

2,6-Dimethyl-4-nitrobenzoic anhydride (DMNBA): An effective coupling reagent for the synthesis of carboxylic esters and lactones

Various carboxylic esters are obtained at room temperature in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols using 2,6-dimethyl-4-nitrobenzoic anhydride with triethylamine by the promotion of 4-(dimethylamino)pyridine. The efficiency of the esterification is compared to those of other dehydrations using substituted benzoic anhydrides as coupling reagents. This method was successfully applied to the synthesis of threo-aleuritic acid lactone and the desired 17-membered ring compound was prepared in high yield at room temperature from the corresponding free trihydroxycarboxylic acid using 2,6-dimethyl-4-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine.

AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR

The present invention provides a compound represented by the following formula (I): [wherein, A represents a group of the following formula (A-1): etc., R1 and R2 each independently represent a hydrogen atom etc., Z represents CR3 etc., W represents CR4 etc., Q represents CR5 etc., R3, R4 and R5 each independently represent a hydrogen atom etc., Y represents an oxygen atom or sulfur atom, X represents an oxygen atom etc. and B represents an optionally substituted aryl group or optionally substituted heteroaryl group], the prodrug thereof or the pharmaceutically acceptable salt thereof for preventing or treating various diseases such as hypertesion, cerebral stroke, cardiac failure, etc.