78269-85-9

Basic information

• Product Name: 1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&
• Synonyms: 1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&;N-[2-(Trimethylsilyl)ethoxycarbonyloxy]succinimide;Teoc-OSu;(TriMethylsilyl)ethoxycarbonyloxy]succiniMide;2,5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)-ethyl) carbonate;1-[[[2-(Trimethylsilyl)ethoxy]carbonyl]oxy]-2,5-pyrrolidinedione;Carbonic acid,2,5-dioxo-1-pyrrolidinyl [2-(triMethylsilyl)ethyl] ester;(triMethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione
• CAS NO: 78269-85-9
• Molecular Formula: C₁₀H₁₇NO₅Si
• Molecular Weight: 259.33
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 78269-85-9.mol

Chemical Properties

• Melting Point: 83-88 °C(lit.)
• Boiling Point: 308.6°C at 760 mmHg
• Flash Point: 140.4°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000675mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: 1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&(78269-85-9)
• EPA Substance Registry System: 1-(2-(TRIMETHYLSILYL)ETHOXYCARBONYLOXY)&(78269-85-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 78269-85-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Teoc-OSu is used as an acylating reagent for the synthesis of Teoc-amino acid derivatives, which are essential in the development of various pharmaceutical compounds. The reagent's ability to form stable derivatives with amino acids makes it a valuable tool in drug discovery and medicinal chemistry.
Used in Chemical Research:
In the field of chemical research, Teoc-OSu is utilized for the preparation of various organic compounds and materials. Its unique silicon-based structure allows for the exploration of new chemical reactions and the synthesis of novel molecules with potential applications in various industries.
Used in Material Science:
Teoc-OSu's silicon-based structure also makes it a candidate for use in material science, where it can be employed in the development of new materials with specific properties. These materials could have applications in electronics, coatings, or other advanced technologies.

InChI:InChI=1/C10H17NO5Si/c1-17(2,3)7-6-15-10(14)16-11-8(12)4-5-9(11)13/h4-7H2,1-3H3

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 74124-79-1 di(succinimido) carbonate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 20160-60-5 2-(trimethylsilyl)-ethoxycarbonyl chloride 

Downstream Products

• 154876-20-7 1-hydrazinecarboxylic acid 2-(trimethylsilyl)ethyl ester 
• 1020834-11-0 C₁₆H₂₇NO₅Si 
• 884513-98-8 C₃₃H₅₆ClN₃O₅Si 
• 1398570-17-6 Ethyl trans-4-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)cyclohexanecarboxylate 
• 1398570-18-7 Trans-4-({[2-(trimethylsilyl)ethoxy]carbonyl}amino)cyclohexanecarboxylic acid 
• 1352835-65-4 2-(trimethylsilyl)ethyl 1H-indol-6-ylcarbamate 
• 1352835-72-3 2-((3-(1-carbamoyl-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-chlorobenzoic acid 
• 1352835-71-2 2-(trimethylsilyl)ethyl 4-(3-amino-2-methylphenyl)-1-carbamoyl-9H-pyrido[3,4-b]indol-7-ylcarbamate 
• 1352835-70-1 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxamide 
• 1352835-69-8 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylic acid 
• 1352835-68-7 ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate 
• 1352835-67-6 C₃₁H₃₈N₄O₄Si 
• 1352835-66-5 C₃₁H₃₆N₄O₆Si 

Relevant articles and documents

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Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing

Synthesis and Evaluation of Novel Activated Mixed Carbonate Reagents for the Introduction of the 2-(Trimethylsilyl)ethoxycarbonyl(Teoc)-Protecting Group

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