784193-14-2Relevant articles and documents
NOVEL INHIBITORS
-
Page/Page column 69; 125, (2014/09/29)
The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R1, R2, R3, R4 and R5 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N- terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
New bicyclic cannabinoid receptor-1 (CB1-R) antagonists
Carpino, Philip A.,Griffith, David A.,Sakya, Subas,Dow, Robert L.,Black, Shawn C.,Hadcock, John R.,Iredale, Philip A.,Scott, Dennis O.,Fichtner, Michael W.,Rose, Colin R.,Day, Robert,Dibrino, Joseph,Butler, Mary,DeBartolo, Demetria B.,Dutcher, Darrin,Gautreau, Denise,Lizano, Jeff S.,O'Connor, Rebecca E.,Sands, Michelle A.,Kelly-Sullivan, Dawn,Ward, Karen M.
, p. 731 - 736 (2007/10/03)
A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB1-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-
Cannabinoid receptor ligands and uses thereof
-
Page 19, (2010/02/09)
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.
CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
-
Page 33, (2010/02/09)
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.