78891-38-0Relevant articles and documents
Synthesis of the Bacterial Coenzyme Methoxatin
Gainor, James A.,Weinreb, Steven M.
, p. 2833 - 2837 (1982)
The details of a total synthesis of methoxatin (1), the coenzyme of several bacterial alcohol dehydrogenases, are presented.Methoxatin has been prepared in 13 steps by starting from 2,3-dimethoxytoluene.The successful synthetic strategy for construction of the coenzyme used a Pfitzinger synthesis for preparation of the quinoline dicarboxylic acid portion of 1 and an "umpolung" variation of the Reissert indole synthesis for annulation of the remaining pyrrole ring.