79207-43-5

Basic information

• Product Name: 1-(4-SULFONO MORPHOLINE)ACETONITRILE
• Synonyms: 1-(4-SULFONO MORPHOLINE)ACETONITRILE;1-DIOXIDE-4-THIOMORPHOLINEACETONITRILE;4-THIOMORPHOLINE ACETONITRILE, 1,1-DIOXIDE
• CAS NO: 79207-43-5
• Molecular Formula: C₆H₁₀N₂O₂S
• Molecular Weight: 174.22
• Mol File: 79207-43-5.mol

Chemical Properties

• Boiling Point: 401.3°C at 760 mmHg
• Flash Point: 196.5°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 1-(4-SULFONO MORPHOLINE)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-SULFONO MORPHOLINE)ACETONITRILE(79207-43-5)
• EPA Substance Registry System: 1-(4-SULFONO MORPHOLINE)ACETONITRILE(79207-43-5)

Safety Data

• Hazardous Substances Data: 79207-43-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-SULFONO MORPHOLINE)ACETONITRILE is used as an intermediate for the development of pharmaceuticals, contributing to the creation of new medications and therapies.
Used in Agrochemical Production:
In the agrochemical industry, 1-(4-SULFONO MORPHOLINE)ACETONITRILE serves as an intermediate, playing a crucial role in the synthesis of compounds that are utilized in agriculture to protect crops and enhance their yield.
Used in Dye Manufacturing:
1-(4-SULFONO MORPHOLINE)ACETONITRILE is also employed as an intermediate in the production of dyes, which are essential for coloring various materials in different industries, including textiles and plastics.
Used as a Building Block in Organic Compound Preparation:
1-(4-SULFONO MORPHOLINE)ACETONITRILE is used as a building block for preparing various organic compounds, highlighting its importance in the field of organic chemistry.
Used as a Reagent in Organic Synthesis:
Due to its versatile nature, 1-(4-SULFONO MORPHOLINE)ACETONITRILE is a valuable reagent in a wide range of chemical reactions, further expanding its applications across various industries.

InChI:InChI=1/C6H10N2O2S/c7-1-2-8-3-5-11(9,10)6-4-8/h2-6H2

Upstream product

• 39093-93-1 thiomorpholine 1,1-dioxide 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 89937-52-0 2-(1,1-Dioxo-thiomorpholin-4-yl)-ethylamine 
• 1226916-86-4 N-[2-(1,1-Dioxidothiomorpholin-4-yl)ethyl]-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine-2-amine 

Relevant articles and documents

Aryl compounds with aminoalkyl substituents and their use

The present application relates to novel aryl compounds with aminoalkyl substituents, to processes for their preparation, to their use for treatment and/or prevention of diseases and to their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

Concerning the Reactivity of Unsubstituted and Alkyl Substituted Thiomorpholines, 5. On the Joint Action of Elementary Sulfur and Gaseous Ammonia on Ketones, 95

The syntheses of 4-amino-thiomorpholine-1,1-dioxide (12) and 4-hydroxy-thiomorpholine-1,1-dioxide (11) from 1,4-thioxane-1,1-dioxide (1) by pressureless reaction of 1 with hydrazine hydrate and hydroxylamine, resp. is described.In analogy various other N-substituted thiomorpholine-1,1-dioxides are obtained with prim. amines (2-8) and diamines (9,10). 12 condensates with aldehydes (14-24) and ketones (25-29); reaction of 12 with 1 gives N,N'-dithiomorpholine-1,1-dioxide (13).Acylation of 12 with monochlorides (30-35), dichlorides of dicarboxylic acids (36-40) and carbo xylic acid anhydrides (41-43) proceeds smoothly.Compounds 38-43 are cyclic imides.Isocyanates give with 12 the expected compounds 45-48. 12 reacts with chlorinated 1,3,5-triazines to compounds which can be purified only with difficulty (49-51).Quaternization of the N-substituted thiomorpholine-1,1-dioxides with benzylbromide (52,53) and methyliodide (54,55) is possible.Ethylenbromide reacts with 9 to give the bis quaternization product 56.Further reactions of thiomorpholine-1,1-dioxide (57) with sulfuryl chloride (58), bromo cyanide (59), allylic chloride (60), chloro acetonitrile (61) and trityl chloride (62) are described. 11 reacts with carboxylic acid chlorides (63-65) and iso-cyanates (66-70) to yield the expected compounds.Propylene oxide gives with 12 the addition product 71; sulfur dioxide is added to 11 to thiomorpholine-1,1-dioxide sulfonic acid (72). - Keywords: 4-Aminothiomorpholine-1,1-dioxide; 4-Hydroxy-thiomorpholine-1,1-dioxide; Reactivity; Synthesis.