79379-93-4

Basic information

• Product Name: 4,5-Isoxazoledicarboxylic acid, 3-benzoyl-, dimethyl ester
• CAS NO: 79379-93-4
• Molecular Formula: C14H11NO6
• Molecular Weight: 289.244
• Mol File: 79379-93-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4,5-Isoxazoledicarboxylic acid, 3-benzoyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Isoxazoledicarboxylic acid, 3-benzoyl-, dimethyl ester(79379-93-4)
• EPA Substance Registry System: 4,5-Isoxazoledicarboxylic acid, 3-benzoyl-, dimethyl ester(79379-93-4)

Safety Data

• Hazardous Substances Data: 79379-93-4(Hazardous Substances Data)

Upstream product

• 874008-12-5 3-Hexin-1,6-dicarbonsaeure-dimethylester 
• 614-21-1 2-nitroacetophenone 
• 536-74-3 phenylacetylene 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 1829-60-3 dimethyl 7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate 

Relevant articles and documents

A Facile Approach to the Synthesis of 3-Acylisoxazole Derivatives with Reusable Solid Acid Catalysts

Nitrile oxides were formed from nitro ketones using silica gel-supported sodium hydrogen sulfate (NaHSO4/SiO2) or Amberlyst 15 as solid acid catalyst, and then the corresponding 3-acylisoxaszoles were obtained by reacting with alkynes via the 1,3-dipolar [3+2] cycloaddition. These heterogeneous catalysts are easily separable from the reaction mixture and reused. This synthetic method provides a facile, efficient, and reusable production of 3-acylisoxazoles.

Isoxazole compounds and synthetic method thereof

The invention relates to a kind of isoxazole compounds and a synthetic method thereof. The structural formula of the compounds is shown in the specification, R1 is chlorophenyl, methylphenyl or acetylphenyl, R2 is hydrogen or methyl formate, and R3 is methyl formate, ethyl formate or phenoxymethyl. The substituted isoxazole compounds are a kind of important organic reaction intermediates, and can be used to conveniently rapidly synthesize a series of aromatic isoxazole derivatives through different types of organic chemical reactions, such as ring-opening reaction, addition reaction, substitution reaction and the like. The method raw materials are simple and easy to obtain. Cupric nitrate trihydrate is employed as a novel nitrogen source and oxygen source, and possesses best reaction activity under promotion effect of copper. Also, routine reaction solvents are employed, operation is simple, conditions are mild, the reaction is friendly to environment, the yield is medium to excellent, and extremely good development prospect in industrial production is provided.

Synthesis of pyrrolo[2,1-a]isoquinolines from activated acetylenes, benzoylnitromethanes, and isoquinoline

Isoquinoline reacts smoothly with aroylnitromethanes in the presence of dialkyl acetylenedicarboxylates and dibenzoylacetylene to produce pyrrolo[2,1-a]isoquinolines in good yields. Quinoline and benzothiazole also react in a similar way. Pyridine and N-m