796119-63-6Relevant articles and documents
NOVEL INHIBITORS OF MAP4K1
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Page/Page column 63; 64, (2018/12/13)
The invention relates to novel inhibitors of MAP4K1 (HPK1) useful for the treatment of diseases or disorders characterised by dysregulation of the signal transduction pathways associated with MAPK activation, including hyperproliferative diseases, diseases of immune system dysfunction, inflammatory disorders, neurological diseases, and cardiovascular diseases. The invention further relates to pharmaceutical compositions comprising the same and methods of treatment of said diseases and disorders. The inhibitors are of formula (I) wherein the definitions for A, D, E, F, R5, R6, R7, Z, ring Q, n, x and y are as given in the application.
Substituted oxyarenes
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, (2008/06/13)
The invention relates to compounds of formula (I), wherein A1, A2, R1, R2, R3, R4, R5, and Y have the meaning indicated in the description, methods and intermediate compounds for the production thereof, and the use thereof for controlling pests.