328-67-6

Usage

Chemical Properties

Solid

InChI:InChI=1/C8H4BrF3O2/c9-6-2-4(7(13)14)1-5(3-6)8(10,11)12/h1-3H,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 481075-59-6 1-bromo-3-iodo-5-(trifluoromethyl)benzene 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 328-68-7 3-amino-5-(trifluoromethyl)benzoic acid 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 481075-58-5 2-bromo-1-iodo-4-(trifluoromethyl)benzene 

Downstream Products

• 187331-46-0 3-bromo-5-trifluoromethylbenzoic acid methyl ester 
• 172023-97-1 (3‐bromo‐5‐(trifluoromethyl)phenyl)methanol 
• 1264616-23-0 C₁₂H₁₃BF₃NO₃ 
• 1264616-26-3 C₁₂H₁₃BF₃NO₄ 
• 1264616-29-6 3-(4-chlorophenylcarbamoyl)-5-trifluoromethylphenylboronic acid 
• 930783-06-5 3-bromo-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4-acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide 
• 917572-25-9 3-bromo-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)benzamide 
• 880652-44-8 3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Dibenzyl Amine Compounds and Derivatives

Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Alkynyl compounds as non nucleoside reverse transcriptase inhibitors

Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table. R1R2R4Rs

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization

It was possible to functionalize the three fluorobenzyl alcohols and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids accessible in 63% average yield. Moreover, the TIPS group tolerates weakly basic and acidic media and, therefore, may facilitate further structural elaboration. The unprotected alcohols reacted more sluggishly and were unable to provide two of the targeted products (acids 1 and 2). The yield averaged only 46% in the five other cases (acids 3-7). The direct metalation of fluorinated benzyl and phenethyl alcohols remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcohols and two of the three (trifluoromethyl)phenethyl alcohol isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total of nine new benzoic acids or lactones (compounds 8-14 and 17-18). Despite the poor yields (31% on average), the organometallic methods employed are, in general, extremely selective, economical and easy to perform. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.