800401-65-4

Basic information

• Product Name: 5-AZAINDOLE-2-CARBOXYLIC ACID
• Synonyms: 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID;5-AZAINDOLE-2-CARBOXYLIC ACID;5-Azaindole-5-carboxylic acid;1H-pyrrolo[3,2-c]pyridine-2-carbo×ylic acid;[3,2-c]pyridine-2-carboxylic acid
• CAS NO: 800401-65-4
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.15
• EINECS: 1.506 g/cm³
• Product Categories: Azaindoles
• Mol File: 800401-65-4.mol

Chemical Properties

• Boiling Point: 446.8 °C at 760 mmHg
• Flash Point: 224 °C
• Appearance: /
• Density: 1.507g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: 2-8°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 3.44±0.30(Predicted)
• CAS DataBase Reference: 5-AZAINDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AZAINDOLE-2-CARBOXYLIC ACID(800401-65-4)
• EPA Substance Registry System: 5-AZAINDOLE-2-CARBOXYLIC ACID(800401-65-4)

Safety Data

• Hazardous Substances Data: 800401-65-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Azaindole-2-carboxylic Acid is used as a synthetic intermediate for the development of various pharmaceutical agents. Its unique azaindole structure is expected to contribute to the creation of novel drug molecules with potential therapeutic applications.
Used in Medicinal Chemistry Research:
5-Azaindole-2-carboxylic Acid is utilized as a research compound in medicinal chemistry, where its properties and potential applications are being explored. 5-AZAINDOLE-2-CARBOXYLIC ACID's structure may offer insights into new drug design strategies and synthesis methods, furthering the understanding of its role in pharmaceutical development.

InChI:InChI=1/C8H6N2O2/c11-8(12)7-3-5-4-9-2-1-6(5)10-7/h1-4,10H,(H,11,12)

Upstream product

• 800401-64-3 ethyl 1H-pyrrolo[3,2-c]pyridine-2-carboxylate 
• 271-34-1 5-azaindole 
• 504-24-5 4-aminopyridine 
• 88511-27-7 3-iodopyridin-4-amine 
• 127-17-3 2-oxo-propionic acid 
• 1990-90-5 4-amino-3-methylpyridine 

Relevant articles and documents

A medicine intermediate 5 - aza indole synthesis method (by machine translation)

The present invention discloses a pharmaceutical intermediate 5 - aza indole synthesis method, comprises the following steps: the 3 - methyl - 4 - aminopyridine with acetone after mixing, heating to 40 - 60 °C, adding catalyst after adding the oxalate, under stirring conditions, refluxing reaction 1 - 2 h, filtering, the filtrate by reduced pressure distillation, recrystallization, prepared 4 - aminopyridine - 3 - pyruvate ester; in its entry into the DMA, adding salicylic acid then adding the FeO, heated to 60 - 70 °C, stirring reflux reaction for 2 - 3 h, filter, the filtrate is distilled under reduced pressure, to obtain 5 - aza indole - 2 - carboxylic acid; and after mixing with the carbon tetrachloride, heating to 70 - 90 °C, adding ZnO mixing, stirring reflux reaction for 2 - 3 h after, filtering, the filtrate is distilled under reduced pressure, to obtain 5 - azaindole. The application of the synthesis method is simple in operation, mild condition, less by-products, the product has high purity, product yield is relatively high. (by machine translation)

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES

Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.

AMIDO-BENZYL SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat

ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES

The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).