80224-89-1

Basic information

• Product Name: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• Synonyms: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• CAS NO: 80224-89-1
• Molecular Weight: 255.703
• Mol File: 80224-89-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)
• EPA Substance Registry System: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)

Safety Data

• Hazardous Substances Data: 80224-89-1(Hazardous Substances Data)

Upstream product

• 3282-33-5 1-(4-chlorophenyl)-2-diazoethanone 
• 100-47-0 benzonitrile 
• 5468-33-7 1-(4-chlorophenyl)-2-nitroethan-1-one 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 55-21-0 benzamide 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 100-46-9 benzylamine 
• 3418-95-9 1-(benzoylamino)-2-(4-chlorophenyl)ethane 
• 873-73-4 4-n-chlorophenylacetylene 
• 2835-06-5 phenylglycin 
• 61650-22-4 N-(pivaloyloxy)benzamide 
• 1073-67-2 4-vinylbenzyl chloride 
• 622-79-7 benzyl azide 

Relevant articles and documents

Divergent Conversion of N-Acyl-isoxazol-5(2 H)-ones to Oxazoles and 1,3-Oxazin-6-ones Using Photoredox Catalysis

The fragmentation of N-acyl-isoxazol-5-ones using visible light photoredox catalysis has been disclosed. The catalyst-controlled divergent mechanisms, namely the oxidative and reductive quenching catalytic cycle, are utilized. Various oxazoles and 1,3-oxazin-6-ones are selectively obtained from the same isoxazol-5-one skeleton under mild conditions.

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

A facile synthesis of 2,5-disubstituted oxazoles via a copper-catalyzed cascade reaction of alkenes with azides

A novel and efficient approach to the synthesis of 2,5-disubstituted oxazoles is developed via a 1,3-dipolar cycloaddition/ring cleavage/1,2-H migration/denitrogenation/copper-catalyzed aerobic oxidative dehydrogenative cyclization cascade. The desired products can be obtained from readily available aromatic terminal alkenes and azides employing air as the oxidant under mild conditions, and it offers an attractive alternative method for the synthesis of oxazole derivatives.