3282-33-5

Basic information

• Product Name: [2-(4-chlorophenyl)-2-oxoethylidene]diazenium
• CAS NO: 3282-33-5
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 181.5985
• Mol File: 3282-33-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: [2-(4-chlorophenyl)-2-oxoethylidene]diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-chlorophenyl)-2-oxoethylidene]diazenium(3282-33-5)
• EPA Substance Registry System: [2-(4-chlorophenyl)-2-oxoethylidene]diazenium(3282-33-5)

Safety Data

• Hazardous Substances Data: 3282-33-5(Hazardous Substances Data)

Usage

General Description

[2-(4-chlorophenyl)-2-oxoethylidene]diazenium is a chemical compound that contains a diazeniumdiolate functional group. It is also known as "ONO-1714", and it has been studied for its potential as a nitric oxide donor in pharmaceutical and biological research. Nitric oxide is a signaling molecule that plays a critical role in many physiological processes, including smooth muscle relaxation, immune response, and neurotransmission. The diazeniumdiolate group has the ability to release nitric oxide in a controlled and sustained manner, making it a promising candidate for the development of nitric oxide-based therapies. Research on [2-(4-chlorophenyl)-2-oxoethylidene]diazenium continues to explore its potential applications in the treatment of various medical conditions, including cardiovascular disease, cancer, and inflammatory disorders.

Upstream product

• 186581-53-3 diazomethane 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 4996-21-8 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone 
• 99-91-2 para-chloroacetophenone 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 18362-49-7 1,3-bis(4-chlorophenyl)propane-1,3-dione 
• 277298-60-9 C₈H₆Cl₂N₂O 
• 33074-12-3 2-diazo-1,3-bis(4-chlorophenyl)propane-1,3-dione 
• 56856-73-6 3-(4-chlorophenyl)-3-ketopropionaldehyde 
• 53704-16-8 sodium salt of ω-formyl-4-chloroacetophenone 

Downstream Products

• 39561-82-5 4-chlorophenacyl acetate 
• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 5905-11-3 2-(4-chlorophenyl)-1-methyl-2-phenyl-1H-indole 
• 107915-10-6 3-(4-chlorophenyl)-1-methyl-1H-indole 
• 64873-61-6 (4-chloro-phenyl)-(5-ethylsulfanyl-[1,3,4]thiadiazol-2-yl)-methanone 
• 22177-11-3 allyl-[5-(4-chloro-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-amine 
• 95877-07-9 [4-(4-chloro-benzoyl)-[1,2,3]thiadiazol-5-yl]-sulfamic acid ethyl ester 
• 93260-80-1 N-[4-(4-chloro-benzoyl)-[1,2,3]thiadiazol-5-yl]-2-methyl-benzamide 
• 23808-75-5 (4-bromo-phenyl)-[3-(4-bromo-phenyl)-4-(4-chloro-phenyl)-3H-thiazol-2-ylidene]-amine 
• 21443-48-1 3,4-bis(4'-chlorobenzoyl)-1,2,5-oxadiazole-2-oxide 
• 23808-76-6 [4-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-3H-thiazol-2-ylidene]-(4-methoxy-phenyl)-amine 
• 25594-98-3 2-methyl-5-(3′-methylphenyl)oxazole 
• 30780-45-1 1-(4-chlorophenyl)-2-methoxyethan-1-one 
• 77901-30-5 1-(4-Chloro-phenyl)-2-(2,4,6-trimethoxy-phenyl)-ethanone 

Relevant articles and documents

Practical Application of the Aqueous 'Sulfonyl-Azide-Free' (SAFE) Diazo Transfer Protocol to Less α-C-H Acidic Ketones and Esters

The earlier described 'sulfonyl-Azide-free' ('SAFE') protocol for diazo transfer to CH-Acidic 1,3-dicarbonyl compounds (and their similarly activated congeners) has been extended to the less reactive monocarbonyl substrates, which previously required a se

Metal-Free Insertion Reactions of Diazo Carbonyls to Azlactones

Insertion reactions of diazo carbonyls to azlactones in basic conditions have been performed. The developed method allows the preparation of a wide range of oxazole derivatives in yields ranging from 74 to 98%. Different substituents on both azlactone rings and diazo carbonyls do not compromise the methodology, even those containing stereogenic centers. Isotopic labeling experiments revealed the mechanism may proceed through a rare diazo carbonyl activation by an ammonium salt derivative.

One-pot synthesis of polyfunctional pyrazoles: An easy access to α-diazoketones from arylglyoxal monohydrates and tosylhydrazine

A new and efficient method for the generation of α-diazoketones has been developed from arylglyoxal monohydrates and tosylhydrazine at room temperature. 1,3-Dipolar cycloaddition reactions were used to constructing polyfunctional pyrazole derivatives by the reaction of generated α-diazoketones in situ with electron-deficient alkenes, quinones and coumarins in one pot. The one-dimensional molecular packing of 1H-benzo[f]indazole-4,9-dione derivatives along the c direction demonstrated a helical chain formation via N-H?O hydrogen-bonding.