80442-87-1Relevant articles and documents
Subtype selective substrates for histone deacetylases
Heltweg, Birgit,Dequiedt, Franck,Marshall, Brett L.,Brauch, Carsten,Yoshida, Minoru,Nishino, Norikazu,Verdin, Eric,Jung, Manfred
, p. 5235 - 5243 (2007/10/03)
To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver, human HeLa, and human recombinant class I and II histon