822-83-3

Basic information

• Product Name: 2-propan-2-yl-1,3-dioxolane
• Synonyms: 2-propan-2-yl-1,3-dioxolane;2-Isopropyl-1,3-dioxolane;2-Methylpropanal ethylene acetal
• CAS NO: 822-83-3
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• Mol File: 822-83-3.mol

Chemical Properties

• Boiling Point: 130°C at 760 mmHg
• Flash Point: 32.3°C
• Appearance: /
• Density: 0.945g/cm³
• Vapor Pressure: 12.1mmHg at 25°C
• Refractive Index: 1.417
• CAS DataBase Reference: 2-propan-2-yl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propan-2-yl-1,3-dioxolane(822-83-3)
• EPA Substance Registry System: 2-propan-2-yl-1,3-dioxolane(822-83-3)

Safety Data

• Hazardous Substances Data: 822-83-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-propan-2-yl-1,3-dioxolane serves as a versatile intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of complex organic molecules that can target specific biological pathways, making it valuable for developing new drugs and therapies.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-propan-2-yl-1,3-dioxolane is utilized as a building block for synthesizing a wide range of organic compounds. Its ability to form stable intermediates and participate in various chemical reactions makes it a useful component in the creation of specialty chemicals, agrochemicals, and other related products.
Used in Solvent Applications:
Due to its solubility properties and relatively low toxicity, 2-propan-2-yl-1,3-dioxolane can be employed as a solvent in various industrial processes. It is particularly useful in applications where a non-polar solvent is required, such as in the extraction, purification, or synthesis of certain organic compounds.
Used in Research and Development:
2-propan-2-yl-1,3-dioxolane is also used in academic and industrial research settings to explore its potential applications and properties. Scientists and researchers can leverage its unique structure to investigate new chemical reactions, mechanisms, and the development of novel materials and compounds.

InChI:InChI=1/C6H12O2/c1-5(2)6-7-3-4-8-6/h5-6H,3-4H2,1-2H3

Upstream product

• 107-21-1 ethylene glycol 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 4439-24-1 2-isobutoxyethanol 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 624-49-7 dimethylfumarate 
• 6942-58-1 2-hydroxyethyl isobutyrate 
• 97-62-1 Ethyl isobutyrate 
• 33662-96-3 isobutyric acid-(2-chloro-ethyl ester) 
• 107-21-1 ethylene glycol 
• 78-84-2 isobutyraldehyde 

Relevant articles and documents

Robust acidic pseudo-ionic liquid catalyst with self-separation ability for esterification and acetalization

The novel acidic pseudo-ionic liquid catalyst with self-separation ability has been synthesized through the quaternization of triphenylphosphine and the acidification with silicotungstic acid. The pseudo-IL showed high activities for the esterification with average conversions over 90%. The pseudo-IL showed even higher activities for acetalization than traditional sulfuric acid. The homogeneous catalytic process benefited the mass transfer efficiency. The pseudo-IL separated from the reaction mixture automatically after reactions, which was superior to other IL catalysts. The high catalytic activities, easy reusability and high stability were the key properties of the novel catalyst, which hold great potential for green chemical processes.

Synthesis of ethers and cyclic acetals in the presence of CBV-720 zeolite

СBV-720 zeolite was compared to H-Beta zeolite and KU-2 cation-exchange resin in the catalytic performance in addition of alcohols to norbornene, in condensation of aldehyde and ketone with di- and triols, and in the Prins reaction of olefins with formaldehyde. These reactions, when performed on СBV-720 zeolite, occur 1.5–2 times faster than on the other catalysts. The corresponding ethers and cyclic acetals were synthesized.

Synthesis and bactericidal activity of substituted cyclic acetals

A series of substituted cyclic acetals were synthesized and tested for their bactericidal activity against bacteria strain Azospirillum brasilense Sp245.

Bis(perfluorooctanesulfonyl)imide supported on fluorous silica gel: Application to protection of carbonyls

The immobilization of bis(perfluorooctanesulfonyl)imide (HNPf2) on fluorous silica gel (FSG) and its utilization in protection of carbonyls have been investigated. This system is reasonably general and can be applied to converting several carbonyls to the corresponding acetals and ketals in good to excellent yields. There is no need for the use of anhydrous solvents or inert atmosphere. Recycling studies have shown that the FSG-supported HNPf2 catalyst can be readily recovered and reused several times without significant loss of activity.

A convenient and highly efficient method for the protection of aldehydes using very low loading hydrous ruthenium(III) trichloride as catalyst

A convenient method for the chemoselective protections of both aliphatic and aromatic aldehydes has been developed. Ruthenium(III) trichloride (0.1 mol %) has found to be an highly efficient catalyst in the acetalizations of aldehydes with various simple alcohols such as methanol, ethanol, or diols such as 1,2-ethylanediol and 1,3-propanediol under mild reaction conditions.

Identification of 1,3-dioxanes and 1,3-dioxolanes as malodorous compounds at trace levels in river water, groundwater, and tap water

A study of organic compounds imparting odor problems in river waters and groundwaters has been conducted. The Tordera aquifer located in Barcelona and Girona (NE Spain) is the water supply reserve for many seasonally crowded villages on the coast. Closed loop stripping analysis (CLSA) and flavor profile analysis (FPA) have been employed as analytical tools to identify the compounds responsible for the odor complaints. The feasibility of purge-and- trap (P and T) has also been evaluated. The 2-alkyl-5,5-dimethyl-1,3-dioxanes and 2-alkyl-4-methyl-1,3-dioxolanes were the most significant compounds identified in river water and groundwater with a threshold odor of 10 ng/L for 2-ethyl-5,5-dimethyl-1,3-dioxane (2EDD), the most malodorous compound. The analyses were carried out by HRGC/MS, and the synthesized 1,3-dioxanes and dioxolanes were characterized by CI-MS and EI-MS/MS techniques. A company, currently manufacturing saturated and unsaturated polyester resins, located in the upper course of the river, produced these compounds as byproducts during the synthesis of resins. The pollution by dioxanes and dioxolanes affected all the aquifer and slowly diminished to the ppt levels when the company was forced to correctly treat their wastewaters. Additional examples of the presence of dioxanes and dioxolanes in wastewaters of other resin plants and also tap water of Barcelona are shown. A study of organic compounds imparting odor problems in river waters and groundwaters has been conducted. The Tordera aquifer located in Barcelona and Girona (NE Spain) is the water supply reserve for many seasonally crowded villages on the coast. Closed loop stripping analysis (CLSA) and flavor profile analysis (FPA) have been employed as analytical tools to identify the compounds responsible for the odor complaints. The feasibility of purge-and-trap (P&T) has also been evaluated. The 2-alkyl-5,5-dimethyl-1,3-dioxanes and 2-alkyl-4-methyl-1,3-dioxolanes were the most significant compounds identified in river water and groundwater with a threshold odor of 10 ng/L for 2-ethyl-5,5-dimethyl-1,3-dioxane (2EDD), the most malodorous compound. The analyses were carried out by HRGC/MS, and the synthesized 1,3-dioxanes and dioxolanes were characterized by CI-MS and EI-MS/MS techniques. A company, currently manufacturing saturated and unsaturated polyester resins, located in the upper course of the river, produced these compounds as byproducts during the synthesis of resins. The pollution by dioxanes and dioxolanes affected all the aquifer and slowly diminished to the ppt levels when the company was forced to correctly treat their wastewaters. Additional examples of the presence of dioxanes and dioxolanes in wastewaters of other resin plants and also tap water of Barcelona are shown.

SYNTHESIS OF CYCLIC ACETALS FROM ALDEHYDES AND DIOLS MEDIATED BY BUTYLTIN TRICHLORIDE

A facile and convenient method for the preparation of cyclic acetals from aldehydes and diols utilizing butyltin trichloride as acid catalyst and dehydrating agent is proposed.Some 2-alkyl-1,3-dioxolanes and -dioxans (alkyl = Et and i-Pr) have been prepared under mild conditions. 2-vinyl-1,3-dioxan has also been produced by transacetalization from acrolein dimethyl acetal and 1,3-propanediol.