825645-30-5Relevant articles and documents
Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H- imidazolyl)-5-butylate isoxazolidine
Sadashiva,Mallesha,Murthy, K. Karunakara,Rangappa
, p. 1811 - 1814 (2005)
The trans rich isomer, 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5- butylate isoxazolidine A (>96% ee) was synthesized by the condensation of E isomer rich nitrone 4 (>98% ee) with butyl acrylate in an inert solvent. Obtained isoxazolidine was screened for its antifungal activity against Aspergillus niger, Cephalosporium acremonium, Fusarium moniliforme by using Nystatin as positive control. It was also tested for its antibacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus by using Streptomycin as positive control. Enhanced antifungal activity was observed in isoxazolidine of >96% ee compared to the isoxazolidine of >69% ee (B), and enhancement was not observed in antibacterial activity.
Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines
Sadashiva,Mallesha,Hitesh,Rangappa
, p. 6389 - 6395 (2007/10/03)
Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against Staphylococcus aureus, Escherichia coli and Bacillus subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against Fusarium moniliforme, Aspergillus niger and Cephalosporium acremonium by using nystatin as positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against F. moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared.