83316-92-1Relevant articles and documents
Synthesis of the five peptide derivatives needed to build the sequence corresponding to 1-30 of human epidermal growth factor (h-EGF).
Shin,Kaburaki,Watanabe,Munekata
, p. 399 - 403 (2007/10/02)
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Design of the Synthetic Route for Peptides and Proteins Based on the Solubility Prediction Method. I. Synthesis and Solubility Properties of Human Proinsulin C-Peptide Fragments
Narita Mitsuaki,Ogura, Toshihiko,Sato, Kazuhiro,Honda, Shinya
, p. 2433 - 2438 (2007/10/02)
The usefulness of the solubility prediction method is demonstrated using relatively small peptide fragments of human proinsulin C-peptide.The propriety of the solubility prediction method for peptides having polar side chains is also examined in the following respects: (1) Peptide intermediates smaller than a heptapeptide have high solubility regardless of their c> values; (2) the c> values of peptide intermediates are useful for judging solubility of peptide intermediates equal to or larger than an octapeptide level; (3) the Pro residue in a central position of a peptide chain is effective for increasing peptide solubility; and (4) there is critical chain length for peptide insolubility caused by a β-sheet aggregation.A strategy suitable for the design of the synthetic route or human proinsulin C-peptide is subsequently discussed on the basis of the solubility prediction of peptide intermediates.
