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CAS

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834-28-6

Phenformin hydrochloride is an orally administered biguanide derivative that has the potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. It improves insulin sensitivity and decreases insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. However, it has been withdrawn from clinical use due to its association with inducing lactic acidosis when not metabolized sufficiently.
Used in Anti-diabetic Therapy:
Phenformin hydrochloride is used as an anti-diabetic drug from the biguanide class for improving insulin sensitivity and decreasing insulin resistance in patients with non-insulin-dependent diabetes mellitus.
Used in Erectile Dysfunction Therapy:
Phenformin hydrochloride is used as a therapeutic agent for treating erectile dysfunction.
Used in Anticancer Applications:
Phenformin hydrochloride is used as an anticancer agent for inhibiting the growth of breast cancer cell xenografts in mice through AMPK activation.

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  • 834-28-6 Structure

  • Basic information

    1. Product Name: Phenformin hydrochloride
    2. Synonyms: 1-(diaminomethylene)-2-phenethylguanidine hydrochloride;1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride;1-(diaminomethylidene)-2-phenethylguanidine hydrochloride;1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride;1-Fenetilbiguanide cloridrato [Italian];1-Phen;PHENFORMIN HCL;PHENFORMIN HYDROCHLORIDE
    3. CAS NO:834-28-6
    4. Molecular Formula: C10H15N5*ClH
    5. Molecular Weight: 241.72
    6. EINECS: 212-637-3
    7. Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;VIAGRA
    8. Mol File: 834-28-6.mol

  • Chemical Properties

    1. Melting Point: 175-178°C
    2. Boiling Point: 413.7oC at 760 mmHg
    3. Flash Point: 204oC
    4. Appearance: /
    5. Density: 1.24 g/cm3
    6. Vapor Pressure: 4.71E-07mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: -20°C Freezer
    9. Solubility: Methanol (Slightly), Water (Slightly)
    10. Water Solubility: >=10 g/100 mL at 21 ºC
    11. CAS DataBase Reference: Phenformin hydrochloride(CAS DataBase Reference)
    12. NIST Chemistry Reference: Phenformin hydrochloride(834-28-6)
    13. EPA Substance Registry System: Phenformin hydrochloride(834-28-6)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: 36
    4. WGK Germany: 3
    5. RTECS: DU2200000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 834-28-6(Hazardous Substances Data)

834-28-6 Usage

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 834-28-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,3 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 834-28:
(5*8)+(4*3)+(3*4)+(2*2)+(1*8)=76
76 % 10 = 6
So 834-28-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

834-28-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (PHR1573)  Phenformin Hydrochloride  pharmaceutical secondary standard; traceable to USP

  • 834-28-6

  • PHR1573-500MG

  • 1,027.26CNY

  • Detail

834-28-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Phenformin hydrochloride

1.2 Other means of identification

Product number -
Other names Phenformin HCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:834-28-6 SDS

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