Chemical Property of CID 657277
Chemical Property:
- Appearance/Colour:White powder
- Vapor Pressure:4.71E-07mmHg at 25°C
- Melting Point:175-178 °C
- Boiling Point:413.7oC at 760 mmHg
- Flash Point:204oC
- PSA：97.78000
- Density:1.24 g/cm3
- LogP:2.72010
- Storage Temp.:-20°C Freezer
- Solubility.:Methanol (Slightly), Water (Slightly)
- Water Solubility.:>=10 g/100 mL at 21 ºC
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:4
- Exact Mass:241.1094232
- Heavy Atom Count:16
- Complexity:236
- Purity/Quality:
-
99% *data from raw suppliers
Phenformin hydrochloride
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].C1=CC=C(C=C1)CCN=C(N)N=C(N)N.[Cl-]
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Description
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.
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Uses
erectile dysfunction therapy It is an anti-diabetic drug from the biguanide class It is an anti-diabetic drug from the biguanide class.
