84-85-5

Basic information

• Product Name: 4-METHOXY-1-NAPHTHOL
• Synonyms: 1,4-DIHYDROXYNAPHTHALENE MONOMETHYL ETHER;1-HYDROXY-4-METHOXYNAPHTHALENE;4-METHOXYNAPHTHALEN-1-OL;4-METHOXY-1-NAPHTHOL;4-METHOXY-1-NAPHTHOL, 97+%;4-Methoxy-1-naphthol, 98+%;4-Methoxy-1-naphthol 98%;4-methoxy-1-naphthaleno
• CAS NO: 84-85-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.2
• EINECS: 201-566-3
• Product Categories: Industrial/Fine Chemicals;Naphthalene derivatives
• Mol File: 84-85-5.mol

Chemical Properties

• Melting Point: 126-129 °C(lit.)
• Boiling Point: 265.17°C (rough estimate)
• Flash Point: 228.6 °C
• Appearance: grey to brown-purple crystalline powder
• Density: 1.0844 (rough estimate)
• Vapor Pressure: 2.23E-05mmHg at 25°C
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.24±0.40(Predicted)
• Water Solubility: Soluble in water.
• BRN: 1818465
• CAS DataBase Reference: 4-METHOXY-1-NAPHTHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-1-NAPHTHOL(84-85-5)
• EPA Substance Registry System: 4-METHOXY-1-NAPHTHOL(84-85-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 84-85-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-METHOXY-1-NAPHTHOL is used as a novel antibacterial compound targeting the WalK/WalR two-component signal transduction system of Gram (+) bacteria. It specifically inhibits the WalR response regulator, which is essential for bacterial survival and virulence. This makes it a promising candidate for the development of new antibiotics to combat drug-resistant bacteria.
4-METHOXY-1-NAPHTHOL is also used as a novel human PXR activator, inducing human PXR transcriptional activity. PXR, or pregnane X receptor, is a nuclear receptor that plays a crucial role in the regulation of drug metabolism and transport. Activation of PXR can lead to the upregulation of drug-metabolizing enzymes and transporters, which can improve the efficacy and safety of certain medications.
Used in Chemical Synthesis:
4-METHOXY-1-NAPHTHOL is used in the synthesis of various compounds, including 3-(4-hydroxy-1-naphthoxy)lactic acid (4-HO-NLA). 4-METHOXY-1-NAPHTHOL has potential applications in the development of new drugs and pharmaceuticals, as well as in the chemical industry for the production of dyes, pigments, and other specialty chemicals.

InChI:InChI=1/C11H10O2/c1-13-11-7-6-10(12)8-4-2-3-5-9(8)11/h2-7,12H,1H3

Upstream product

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• 2216-69-5 1-Methoxynaphthalene 
• 64648-84-6 2-Bromo-1,1,4,4-tetramethoxy-1,4-dihydronaphthalene 
• 15971-29-6 4-methoxy-1-naphthaldehyde 
• 33577-96-7 methyl 2-(2-hydroxy-2-methyl-3-butyn-4-yl)benzoate 
• 99893-90-0 4-(2-Bromethoxy)-1-naphthol 
• 73661-04-8 4-(2-chloroethoxy)-1-naphthol 
• 571-60-8 1,4-Dihydroxynaphthalene 

Downstream Products

• 108534-62-9 tert-Butyl-(4-methoxy-naphthalen-1-yloxy)-diphenyl-silane 
• 139016-16-3 (+/-)-trans-2-(4-methoxyphenyl)-2,3-dihydro-5-methoxy-3-methylnaphtho<1,2-b>furan 
• 130-15-4 [1,4]naphthoquinone 
• 853362-15-9 1-methoxy-4-(3-{2-[3-(4-nitro-phenoxy)-prop-1-ynyl]-phenyl}-prop-2-ynyloxy)-naphthalene 
• 82663-57-8 4,4′-dimethoxy-2,2′-binaphthalenyl-1,1′-diol 
• 59699-47-7 4,4’-dimethoxy-2,2’-binaphthalenylidene-1,1’-dione 
• 1616843-54-9 6-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran 
• 18507-09-0 4-Methoxypropranolol 

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