851010-71-4

Basic information

• Product Name: (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone
• Synonyms: (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone
• CAS NO: 851010-71-4
• Molecular Weight: 392.885
• Mol File: 851010-71-4.mol

Chemical Properties

• CAS DataBase Reference: (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone(851010-71-4)
• EPA Substance Registry System: (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone(851010-71-4)

Safety Data

• Hazardous Substances Data: 851010-71-4(Hazardous Substances Data)

Upstream product

• 10177-29-4 4-chloronicotinic acid 
• 100791-00-2 4-chloronicotinoyl chloride 
• 22348-32-9 (S)-diphenylprolinol 

Downstream Products

• 851010-73-6 (S)-(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(4-(pyrrolidin-1-yl)pyridin-3-yl)methanone 

Relevant articles and documents

Asymmetric [3+2] Annulations to Construct 1,2-Bispirooxindoles Incorporating a Dihydropyrrolidine Motif

Constructing chiral bispirooxindoles is difficult to achieve but highly attractive owing to their many potential applications in medicinal chemistry. Here we present an asymmetric [3+2] annulation reaction of Morita–Baylis–Hillman carbonates from isatins and isatin-based N-Boc-ketimines under the catalysis of a newly designed multifunctional 4-dimethylaminopyridine-type substance. The reaction shows high γ-regioselectivity, producing highly complex 1,2-bispirooxindoles incorporating a dihydropyrrolidine motif in excellent yields with moderate to outstanding stereoselectivity (dr>19:1, up to >99% ee). This protocol has been expanded to utilize trifluoromethyl-containing ketimines, delivering complicated architectures with fused and spirocyclic frameworks in modest enantioselectivity. (Figure presented.).

(S)-proline-derived catalysts for the acylative kinetic resolution of alcohols: A remote structural change allows a complete selectivity switch

A systematic preliminary study has identified a suite of catalysts, all readily prepared and derived from (S)-proline, which differ by a remote substituent only. If this substituent is capable of hydrogen-bond donation the catalyst will promote the resolu

Kinetic resolution of sec-alcohols using a new class of readily assembled (S)-proline-derived 4-(pyrrolidino)-pyridine analogues

We report the development of a new class of readily prepared chiral 4-(pyrrolidino)-pyridine catalysts capable of exploiting both van der Waals (π) and H-bonding interactions, thus allowing remote chiral information to stereo-chemically control the kinetic resolution of sec-alcohols. The Royal Society of Chemistry 2005.