871826-15-2

Basic information

• Product Name: (6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE
• Synonyms: TIMTEC-BB SBB010299;ASINEX-REAG BAS 07730925;AURORA KA-268;(6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE;UKRORGSYN-BB BBR-044861;1-(6-CHLOROPYRIDAZIN-3-YL)METHANAMINE;6-Chloro-3-pyridazineMethanaMine;(6-Chloropyridazin-3-yl)methylamine, 3-(Aminomethyl)-6-chloro-1,2-diazine
• CAS NO: 871826-15-2
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.57
• Mol File: 871826-15-2.mol

Chemical Properties

• Melting Point: 97-98 °C
• Boiling Point: 323.5±27.0 °C(Predicted)
• Appearance: /
• Density: 1.338
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.15±0.29(Predicted)
• CAS DataBase Reference: (6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE(871826-15-2)
• EPA Substance Registry System: (6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE(871826-15-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 871826-15-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE is used as a chemical building block for the synthesis of various biologically active compounds. Its unique structure and chemical properties make it a valuable component in the development of potential pharmaceutical drugs.
Used in Medicinal Chemistry Research:
(6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE is utilized as a research tool in medicinal chemistry to explore its potential applications in drug discovery and development. Its structural features allow for the design and synthesis of novel compounds with therapeutic potential.
Used in Drug Development:
(6-CHLORO-PYRIDAZIN-3-YL)-METHYL-AMINE is employed as a key intermediate in the development of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the resulting compounds, making it a crucial element in the optimization of drug candidates for various therapeutic applications.

Upstream product

• 948996-03-0 C₁₃H₈ClN₃O₂ 

Downstream Products

• 344413-28-1 (6-morphoinopyridazin-3-yl)methanamine 

Relevant articles and documents

Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties

A series of novel 2-cyanoacrylates containing different aromatic rings were synthesized, and their structures were characterized by 1H NMR, elemental analysis, and single-crystal X-ray diffraction analysis. Their herbicidal activities against four weeds and inhibition of photosynthetic electron transport against isolated chloroplasts (the Hill reaction) were evaluated. Both in vivo and in vitro data showed that the compounds containing benzene, pyridine, and thiazole moieties gave higher activities than those containing pyrimidine, pyridazine, furan, and tetrahedronfuran moieties. To further explore the comprehensive structure-activity relationship on the basis of in vitro data, comparative molecular field analysis (CoMFA) was performed, and the results showed that a bulky and electronegative group around the para-position of the aromatic rings would have the potential for higher activity, which offered important structural insights into designing highly active compounds prior to the next synthesis.