878650-31-8

Basic information

• Product Name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
• Synonyms: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
• CAS NO: 878650-31-8
• Molecular Formula: C7H6Cl2N2O3
• Molecular Weight: 237.04014
• Mol File: 878650-31-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(878650-31-8)
• EPA Substance Registry System: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(878650-31-8)

Safety Data

• Hazardous Substances Data: 878650-31-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate serves as a crucial intermediate in the production of pesticides and other crop protection agents. Its chemical properties make it suitable for creating compounds that can effectively control pests and diseases in agriculture.
Used in Organic Synthesis:
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate is also utilized in organic synthesis for the preparation of various organic compounds. Its reactivity and functional groups enable chemists to create a wide range of molecules with diverse applications in different industries.

Upstream product

• 7681-38-1 sodium hydrogen sulfate 
• 1446253-05-9 2,6-dichloro-5-methoxypyrimidine-4-carboxaldehyde 
• 1446253-03-7 2,6-dichloro-5-methoxy-4-vinyl pyrimidine 
• 19646-07-2 2,4-dichloro-5-methoxypyrimidine 
• 67-56-1 methanol 

Downstream Products

• 1126320-49-7 methyl 6-amino-2-chloro-5-methoxy-pyrimidine-4-carboxylate 

Relevant articles and documents

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-amino-2-(HETEROCYCLIC)pyrimidine-4-carboxylates AND THEIR USE AS HERBICIDES

4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

NOVEL 4-AMINO-6-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PICOLINATES AND 6-AMINO-2-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinic acids and their derivatives; 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND 6-AMINO-2-(4-SUBSTITUTED-PHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

Provided herein are 4-amino-6-(4-substituted-phenyl)-picolinic acids and their derivatives, and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylic acids and their derivatives, compositions comprising the acids and their derivatives, and methods of use thereof as herbicides.

2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE

2,6-Dihalo-5-alkoxy-4-substituted-pyrimidines, 2,6-dihalo-5-alkoxy-4-pyrimdine carbaldehydes, and derivatives of each are useful intermediates in forming potent herbicides that demonstrate a broad spectrum of weed control. These compounds are disclosed, as are methods of forming and using these compounds.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral RNA. We recently disclosed dihydroxypyrimidine carboxylates 2 as novel, reversible inhibitors of the HCV NS5B polymerase. This series was further developed into 5,6-dihydroxy-2-(2- thienyl)pyrimidine-4-carboxylic acids such as 34 (EC50 9.3 μM), which now show activity in the cell-based HCV replication assay. The structure-activity relationship of these inhibitors is discussed in the context of their physicochemical properties and of the polymerase crystal structure. We also report the results of mutagenesis experiments which support the proposed binding model, which involves pyrophosphate-like chelation of the active site Mg ions.