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Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate, also known as Methyl pyrimidinyl carboxylate, is a chemical compound with the molecular formula C7H6Cl2N2O3. It is a derivative of pyrimidine, featuring two chlorine atoms and a methoxy group attached to the pyrimidine ring, along with a carboxylate ester group. This white to light brown solid is sparingly soluble in water but more soluble in organic solvents. Due to its potential harmful effects if ingested, inhaled, or absorbed through the skin, careful handling is required.

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  • 878650-31-8 Structure
  • Basic information

    1. Product Name: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
    2. Synonyms: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate
    3. CAS NO:878650-31-8
    4. Molecular Formula: C7H6Cl2N2O3
    5. Molecular Weight: 237.04014
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 878650-31-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(878650-31-8)
    11. EPA Substance Registry System: Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate(878650-31-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 878650-31-8(Hazardous Substances Data)

878650-31-8 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate serves as a crucial intermediate in the production of pesticides and other crop protection agents. Its chemical properties make it suitable for creating compounds that can effectively control pests and diseases in agriculture.
Used in Organic Synthesis:
Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate is also utilized in organic synthesis for the preparation of various organic compounds. Its reactivity and functional groups enable chemists to create a wide range of molecules with diverse applications in different industries.

Check Digit Verification of cas no

The CAS Registry Mumber 878650-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,8,6,5 and 0 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 878650-31:
(8*8)+(7*7)+(6*8)+(5*6)+(4*5)+(3*0)+(2*3)+(1*1)=218
218 % 10 = 8
So 878650-31-8 is a valid CAS Registry Number.

878650-31-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2,6-dichloro-5-methoxypyrimidine-4-carboxylate

1.2 Other means of identification

Product number -
Other names methyl 2,6-dichloro-5-methoxy-pyrimidine-4-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:878650-31-8 SDS

878650-31-8Relevant articles and documents

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-amino-2-(HETEROCYCLIC)pyrimidine-4-carboxylates AND THEIR USE AS HERBICIDES

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Paragraph 0214; 0215, (2014/09/29)

4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

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Page/Page column, (2014/09/29)

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

NOVEL 4-AMINO-6-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PICOLINATES AND 6-AMINO-2-(PYRIDYL AND 2-SUBSTITUTEDPHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

-

, (2014/09/29)

4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinic acids and their derivatives; 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their derivatives; and methods of using the same as herbicides.

4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

-

, (2014/09/29)

Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND 6-AMINO-2-(4-SUBSTITUTED-PHENYL)-PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES

-

, (2014/09/29)

Provided herein are 4-amino-6-(4-substituted-phenyl)-picolinic acids and their derivatives, and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylic acids and their derivatives, compositions comprising the acids and their derivatives, and methods of use thereof as herbicides.

2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE

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, (2013/07/19)

2,6-Dihalo-5-alkoxy-4-substituted-pyrimidines, 2,6-dihalo-5-alkoxy-4-pyrimdine carbaldehydes, and derivatives of each are useful intermediates in forming potent herbicides that demonstrate a broad spectrum of weed control. These compounds are disclosed, as are methods of forming and using these compounds.

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis

Koch, Uwe,Attenni, Barbara,Malancona, Savina,Colarusso, Stefania,Conte, Immacolata,Di Filippo, Marcello,Harper, Steven,Pacini, Barbara,Giomini, Claudia,Thomas, Steven,Incitti, Ilario,Tomei, Licia,De Francesco, Raffaele,Altamura, Sergio,Matassa, Victor G.,Narjes, Frank

, p. 1693 - 1705 (2007/10/03)

Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand. The polymerase of HCV is responsible for the replication of viral RNA. We recently disclosed dihydroxypyrimidine carboxylates 2 as novel, reversible inhibitors of the HCV NS5B polymerase. This series was further developed into 5,6-dihydroxy-2-(2- thienyl)pyrimidine-4-carboxylic acids such as 34 (EC50 9.3 μM), which now show activity in the cell-based HCV replication assay. The structure-activity relationship of these inhibitors is discussed in the context of their physicochemical properties and of the polymerase crystal structure. We also report the results of mutagenesis experiments which support the proposed binding model, which involves pyrophosphate-like chelation of the active site Mg ions.

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