879088-87-6

Basic information

• Product Name: 3-Pyridinecarboxamide, 6-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-2-methyl-
• CAS NO: 879088-87-6
• Molecular Formula: C18H13Cl2N3O
• Molecular Weight: 358.227
• Mol File: 879088-87-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, 6-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, 6-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-2-methyl-(879088-87-6)
• EPA Substance Registry System: 3-Pyridinecarboxamide, 6-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-2-methyl-(879088-87-6)

Safety Data

• Hazardous Substances Data: 879088-87-6(Hazardous Substances Data)

Upstream product

• 31163-12-9 ethyl 6-chloro-2-methylnicotinate 
• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 
• 137129-98-7 6-chloro-2-methylpyridine-3-carboxylic acid 

Downstream Products

• 1258238-77-5 C₂₄H₂₆ClN₅O 
• 879087-95-3 C₂₁H₁₇ClN₆O 
• 879088-02-5 C₂₄H₂₄ClN₅O₂ 
• 879088-06-9 C₂₂H₂₃ClN₄O 
• 1258238-76-4 C₂₀H₁₉ClN₄O₂ 

Relevant articles and documents

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clinical lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, respectively, when studied in a Ptch+/- medulloblastoma allograft model, that is, highly dependent on hedgehog signaling.