880495-84-1

Basic information

• Product Name: 2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER;2-((tert-butyldiMethylsilyloxy)Methyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS NO: 880495-84-1
• Molecular Formula: C18H34BNO4Si
• Molecular Weight: 349.35
• Mol File: 880495-84-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER(880495-84-1)
• EPA Substance Registry System: 2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER(880495-84-1)

Safety Data

• Hazardous Substances Data: 880495-84-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER is used as a reagent in organic synthesis for facilitating the formation of carbon-carbon and carbon-heteroatom bonds.
Used in Pharmaceutical Industry:
2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER is used as a building block for the preparation of various pharmaceutical intermediates, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL) PYRIDINE-4-BORONIC ACID PINACOL ESTER is used as a building block for the preparation of various agrochemicals, aiding in the development of new pesticides and other agricultural chemicals.

Upstream product

• 1307231-10-2 4-bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 131747-45-0 4-bromo-2-(hydroxymethyl)pyridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 63071-10-3 (4-chloropyridin-2-yl)methanol 
• 5470-22-4 4-chloropicolinic acid 
• 880495-83-0 C₉H₈ClNO₄ 
• 565237-08-3 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-chloropyridine 

Relevant articles and documents

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds,

Meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst

We report herein the iridium-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2′-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. We also demonstrate the iridium-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. It is proposed that the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp2-hybridized nitrogen atom accelerates the reaction and controls the site-selectivity.

Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus

We synthesized a diverse series of 9H-isothiazolo[5,4-b]quinoline-3,4- diones containing heteroaromatic groups at the 7-position via palladium-catalyzed cross-coupling. Many of these compounds demonstrated potent antistaphylococcal activity (MICs ≤2 μg/mL) against a multi-drug-resistant strain (ATCC 700699) and low cytotoxic activity (CC50 > 100 μM) against the human cell line Hep2 (laryngeal carcinoma).