881637-11-2

Basic information

• Product Name: 2-Aminooxazole-5-carboxylic acid
• Synonyms: 2-Aminooxazole-5-carboxylic acid
• CAS NO: 881637-11-2
• Molecular Formula: C4H4N2O3
• Molecular Weight: 128.08616
• Mol File: 881637-11-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Aminooxazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminooxazole-5-carboxylic acid(881637-11-2)
• EPA Substance Registry System: 2-Aminooxazole-5-carboxylic acid(881637-11-2)

Safety Data

• Hazardous Substances Data: 881637-11-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
2-Aminooxazole-5-carboxylic acid is used as a building block for the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of new therapeutic agents.
Used in Anticancer Applications:
In the field of oncology, 2-Aminooxazole-5-carboxylic acid is studied for its potential therapeutic applications as an anticancer agent. It has shown promise in targeting and treating various types of cancer, making it a valuable candidate for further research and development.
Used in Antimicrobial Applications:
2-Aminooxazole-5-carboxylic acid is also being investigated for its potential use in the treatment of bacterial and fungal infections. Its ability to target and eliminate harmful microorganisms makes it a promising candidate for the development of new antimicrobial agents.
Used in Antioxidant Research:
The antioxidant properties of 2-Aminooxazole-5-carboxylic acid have been explored, with potential applications in the development of new materials and coatings. Its capacity to neutralize harmful free radicals and protect against oxidative stress highlights its potential use in various industries.
Used in Material Science and Coatings Development:
2-Aminooxazole-5-carboxylic acid is being investigated for its potential use in the development of new materials and coatings. Its unique properties and versatility make it a valuable component in the creation of innovative products with enhanced performance characteristics.

Upstream product

• 113853-16-0 2-amino-oxazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase

There is an urgent demand for the development of new antibiotics due to the increase in drug-resistant pathogenic bacteria. A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed step in fatty acid s

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm)

The D-aspartate ligase of Enterococcus faecium (Aslfm) is an attractive target for the development of narrow-spectrum antibacterial agents that are active against multidrug-resistant E. faecium. Although there is currently little available information regarding the structural characteristics of Aslfm, we exploited the knowledge that this enzyme belongs to the ATP-grasp superfamily to target its ATP binding site. In the first design stage, we synthesized and screened a small library of known ATP-competitive inhibitors of ATP-grasp enzymes. A series of amino-oxazoles derived from bacterial biotin carboxylase inhibitors showed low micromolar activity. The most potent inhibitor compound 12, inhibits Aslfm with a Ki value of 2.9 μM. In the second design stage, a validated ligand-based pharmacophore modeling approach was used, taking the newly available inhibition data of an initial series of compounds into account. Experimental evaluation of the virtual screening hits identified two novel structural types of Aslfm inhibitors with 7-amino-9H-purine (18) and 7-amino-1H-pyrazolo[3,4-d]pyrimidine (30 and 34) scaffolds, and also with Ki values in the low micromolar range. Investigation the inhibitors modes of action confirmed that these compounds are competitive with respect to the ATP molecule. The binding of inhibitors to the target enzyme was also studied using isothermal titration calorimetry (ITC). Compounds 6, 12, 18, 30 and 34 represent the first inhibitors of Aslfm reported to date, and are an important step forward in combating infections due to E. faecium.