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Cas Database

886444-12-8

886444-12-8

Identification

  • Product Name:Pyridine, 2-(2-fluorophenyl)-4-methyl-

  • CAS Number: 886444-12-8

  • EINECS:

  • Molecular Weight:187.21300

  • Molecular Formula: C12H10FN

  • HS Code:

  • Mol File:886444-12-8.mol

Synonyms:2-(2-Fluoro-phenyl)-4-methyl-pyridi;2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Crysdot
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95+%
  • Packaging:5g
  • Price:$ 508
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95+%
  • Packaging:25g
  • Price:$ 1782
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95+%
  • Packaging:10g
  • Price:$ 990
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:2-(2-fluorophenyl)-4-methylpyridine 95%
  • Packaging:1g
  • Price:$ 549
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE 95.00%
  • Packaging:5MG
  • Price:$ 495.4
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95%
  • Packaging:1g
  • Price:$ 454
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95%
  • Packaging:250mg
  • Price:$ 145
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:2-(2-Fluorophenyl)-4-methylpyridine 95%
  • Packaging:100mg
  • Price:$ 73
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Copper-catalyzed fluorination of 2-pyridyl aryl bromides

Mu, Xin,Zhang, Hao,Chen, Pinhong,Liu, Guosheng

, p. 275 - 280 (2014/01/06)

Copper(i)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using AgF as the fluorine source. In this transformation a pyridyl directing group is essential for successful catalytic fluorination. A XANES/EXAFS study indicated that the presence of the pyridyl group is essential to stabilize the Cu(i) species and accelerate oxidative addition of the aryl bromide. Further mechanistic studies implicated a Cu(i/iii) catalytic cycle in this Cu(i)-catalyzed fluorination, and final aryl C-F bond formation possibly proceeds through an irreversible reductive elimination of the ArCu(iii)-F species. This rare report of catalytic fluorination by a copper catalyst provides a valuable foundation for further development of Cu(i)-catalyzed fluorination of aryl halides.

Inhibitors of P2X3

-

Page/Page column 23, (2008/06/13)

Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genito-urinary, gastrointestinal, and respiratory disorders: wherein R1 is —C(═S)CH3, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, furyl, furylcarbonyl, acetyl, or carbamoyl; R2a and R2b are independently H, methyl, or ethyl; R3 is H or methyl; Y is a bond, —(CR4R5)n— or —CR4═CR5—; wherein R4 and R5 are each independently H or methyl and n is 1 or 2; X is N or CH; A is phenyl, 5-membered heterocyclyl, or 6-membered heterocyclyl; R6, R7 and R8 are each independently H, halo, lower alkyl, cycloalkyl, alkylthio, alkylthio-lower alkyl, alkylsulfonyl-lower alkyl, di(lower alkyl)amino-lower alkyl, morpholinyl-lower alkyl, 4-methyl-piperazinyl-methyl, trifluoromethyl, pyridyl, tetrazolyl, thiophenyl, phenyl, biphenyl, or benzyl (where thiophenyl, phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoromethyl, lower alkoxy or lower alkylthio) or R6 and R7 together form a 5-membered or 6-membered carbocyclic or heterocyclic ring substituted with 0-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, oxo, halo, thiophenyl-lower alkyl, phenyl, benzyl (where phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoro-methyl, lower alkoxy, lower alkylthio, amino-lower alkyl, lower alkylamino-lower alkyl, or di(lower alkyl)amino-lower alkyl); and pharmaceutically acceptable salts thereof; wherein when R1 is pyrimidin-2-yl, X is N, Y is a bond and A is oxazol-5-yl the carbon atom at position 4 in said oxazol-5-yl is not substituted by propyl when the carbon atom at position 2 in said oxazol-5-yl is substituted by substituted phenyl and the carbon atom at position 4 in said oxazol-5-yl is not substituted by phenyl when the carbon atom at position 2 is substituted by unsubstituted or substituted phenyl.

Process route upstream and downstream products

Process route

tetrakis(triphenylphosphine) palladium<sup>(0)</sup>
14221-01-3

tetrakis(triphenylphosphine) palladium(0)

o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

Conditions
Conditions Yield
With sodium carbonate; In ethanol; diethylene glycol dimethyl ether; at 88 ℃; for 4h;
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

Conditions
Conditions Yield
With {(CuBr(2,9-dimethyl-1,10-phenanthroline))2}; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃; Reagent/catalyst;
78%
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

C<sub>24</sub>H<sub>20</sub>N<sub>2</sub><sup>(18)</sup>O

C24H20N2(18)O

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); 18O-labeled water; In acetonitrile; at 120 ℃;
32%
8%
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

C<sub>24</sub>H<sub>20</sub>N<sub>2</sub><sup>(16)</sup>O

C24H20N2(16)O

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; water-d2; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃; Reagent/catalyst;
18%
11%
methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃;
34%
54%
tetrakis(triphenylphosphine) palladium<sup>(0)</sup>
14221-01-3

tetrakis(triphenylphosphine) palladium(0)

o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

Conditions
Conditions Yield
With sodium carbonate; In ethanol; diethylene glycol dimethyl ether; at 88 ℃; for 4h;
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

Conditions
Conditions Yield
With {(CuBr(2,9-dimethyl-1,10-phenanthroline))2}; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃; Reagent/catalyst;
78%
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

C<sub>24</sub>H<sub>20</sub>N<sub>2</sub><sup>(18)</sup>O

C24H20N2(18)O

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); 18O-labeled water; In acetonitrile; at 120 ℃;
32%
8%
2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

C<sub>24</sub>H<sub>20</sub>N<sub>2</sub><sup>(16)</sup>O

C24H20N2(16)O

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; water-d2; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃; Reagent/catalyst;
18%
11%
methanol
67-56-1

methanol

2-(2-bromophenyl)-4-methylpyridine

2-(2-bromophenyl)-4-methylpyridine

2-(2-fluorophenyl)-4-methylpyridine
886444-12-8

2-(2-fluorophenyl)-4-methylpyridine

2-(2-methoxyphenyl)-4-methylpyridine
100004-77-1

2-(2-methoxyphenyl)-4-methylpyridine

Conditions
Conditions Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; silver fluoride; tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 120 ℃;
34%
54%

Global suppliers and manufacturers

Global( 3) Suppliers
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  • ENAO Chemical Co, Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:86--15307605669
  • Emails:sales@enaochem.com
  • Main Products:1
  • Country:China (Mainland)
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