886444-12-8

Basic information

• Product Name: 2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE
• Synonyms: 2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE
• CAS NO: 886444-12-8
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.2129032
• Mol File: 886444-12-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 277.5°C at 760 mmHg
• Flash Point: 121.6°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 0.00763mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE(886444-12-8)
• EPA Substance Registry System: 2-(2-FLUORO-PHENYL)-4-METHYL-PYRIDINE(886444-12-8)

Safety Data

• Hazardous Substances Data: 886444-12-8(Hazardous Substances Data)

Usage

Structure

Pyridine ring with a methyl group at the 4-position and a fluorophenyl group at the 2-position

Usage

Building block in the synthesis of pharmaceutical compounds and agrochemicals

Potential applications

Medicine and agriculture

Possible properties

Structural and electronic

Biological activities

Unknown, but could be of interest for further research and development

InChI:InChI=1/C12H10FN/c1-9-6-7-14-12(8-9)10-4-2-3-5-11(10)13/h2-8H,1H3

Upstream product

• 67-56-1 methanol 
• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 1993-03-9 o-fluorophenylboronic acid 

Downstream Products

• 924645-91-0 2-(2-fluorophenyl)-pyridine-4-carboxylic acid 
• 886444-14-0 2-[2-(2-fluorophenyl)pyridin-4-yl]-1-(pyridin-2-yl)ethanone 

Relevant articles and documents

Copper-catalyzed fluorination of 2-pyridyl aryl bromides

Copper(i)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using AgF as the fluorine source. In this transformation a pyridyl directing group is essential for successful catalytic fluorination. A XANES/EXAFS study indicated that the presence of the pyridyl group is essential to stabilize the Cu(i) species and accelerate oxidative addition of the aryl bromide. Further mechanistic studies implicated a Cu(i/iii) catalytic cycle in this Cu(i)-catalyzed fluorination, and final aryl C-F bond formation possibly proceeds through an irreversible reductive elimination of the ArCu(iii)-F species. This rare report of catalytic fluorination by a copper catalyst provides a valuable foundation for further development of Cu(i)-catalyzed fluorination of aryl halides.