88876-88-4 Usage
General Description
1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol, also known as Nipradilol, is a chemical compound that belongs to the class of beta blockers and vasodilators. It is typically used in the treatment of conditions such as glaucoma and ocular hypertension, where it works by reducing intraocular pressure and increasing blood flow to the eye. Nipradilol acts as a beta blocker by blocking the effects of adrenaline and other stress hormones on the heart and blood vessels, which helps to lower blood pressure and reduce strain on the heart. Additionally, it also acts as a vasodilator by relaxing the blood vessels, allowing for easier blood flow. This combination of actions makes Nipradilol a useful medication for managing certain cardiovascular and ophthalmic conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 88876-88-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,8,7 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 88876-88:
(7*8)+(6*8)+(5*8)+(4*7)+(3*6)+(2*8)+(1*8)=214
214 % 10 = 4
So 88876-88-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N4O3/c13-7(5-10-3-4-10)6-11-2-1-9-8(11)12(14)15/h1-2,7,13H,3-6H2
88876-88-4Relevant articles and documents
Dual-Function Radiosensitizers. α-methyl>-2-nitro-1H-imidazole-1-ethanol and Related Compounds: Preparation via an Aziridine Equivalent
Suto, Mark J.,Stier, Michael A.,Werbel, Leslie M.
, p. 1207 - 1209 (2007/10/02)
An improved synthesis of the dual-function radiosensitizer α-methyl>-2-nitro-1H-imidazole-1-ethanol (2, RB 6145) has been developed.Previously, the synthetic difficulties associated with this compound limited its attractiveness as a clinical candidate, although its radiosensitizing activity in preclinical models warranted its further development.The synthesis described uses a 2-oxazolidinone as an aziridine equivalent and provides 2 in 47 percent yield.
