9000-71-9

Basic information

• Product Name: Casein
• Synonyms: Casein, vitamin tested;Casein, Hammarsten bovine;ANTI-CSN2 (N-TERM) antibody produced in rabbit;CASB;CSN2;RHODIUM STAND;Bile Salte No.3;Casein, Bovine Milk, Carbohydrate and Fatty Acid Free
• CAS NO: 9000-71-9
• Molecular Weight: 2061.956961
• EINECS: 232-555-1
• Product Categories: starch;Milk Proteins;Biochemicals and Reagents;Proteins and Derivatives;Reagents and Controls for Phosphoprotein Analysis;Phosphorylation Analysis;Post-Translational Modification;General Protease Substrates;Enzymes, Inhibitors, and Substrates;Proteolytic Enzymes and Substrates;Blocking Reagents;Companion Products and ReagentsCell Culture;Insect Platform;Miscellaneous Reagents and Supplements;Reagents and Supplements;Serum-free Media;Blocking ReagentsWestern Blotting;Buffers and Reagents;Buffers, Reagents,&Stains;Substrates, Buffers&Blockers;Supplementary Products;Food&Beverage;Kits for Food Analysis;Special Applications;Base Ingredients;Microbiology;Protein Sources (Peptones/Extracts);protein;proteins
• Mol File: 9000-71-9.mol

Chemical Properties

• Melting Point: 280 °C (dec.)(lit.)
• Appearance: yellow to tan/purified powder
• Storage Temp.: 2-8°C
• Solubility: H2O: insoluble, forms a cloudy suspension
• Water Solubility: SLIGHTLY SOLUBLE
• Sensitive: Hygroscopic
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• Merck: 14,1883
• CAS DataBase Reference: Casein(CAS DataBase Reference)
• NIST Chemistry Reference: Casein(9000-71-9)
• EPA Substance Registry System: Casein(9000-71-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: FI3519500
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 9000-71-9(Hazardous Substances Data)

Usage

Uses

Used in Medical Research:
Casein is used as a research subject for studying insulin-dependent diabetes mellitus (IDDM) in children, due to the strong cross-reactivity of α-casein antibodies with insulin. Higher levels of α-casein antibodies in children with IDDM compared to control siblings may serve as a risk marker for the condition.
Used in Pharmaceutical Applications:
β-Casein is used as a generator of peptides responsible for various biological activities, such as opiate, immunostimulating, antibacterial, and peptidase inhibitory effects.
Used in Food Industry:
Casein is used in the protein fortification of cereals and bread, as well as in the production of fabricated cheeses. The principal form in which casein is used is casein salts, with sodium and calcium caseinate being the most common types. Rennet casein is obtained from skim milk by precipitation with a rennet-type enzyme.

Production Methods

casein is a form of concentrated casein protein (one of the two major proteins found in milk) and is derived from skim milk. Depending on the method of manufacture. casein is classified as rennet casein or acid casein. In the production of rennet casein. skim milk is treated with an enzyme that causes the casein to coagulate and separate from other milk components. Acid casein is produced when skim milk is exposed to an acid treatment which causes the protein to precipitate out from other milk components. Both rennet and acid casein are high- protein products with protein concentrations from 85 to 90 percent. Both rennet and acid casein also contain very little whey protein and therefore cannot be classified as MPC. All forms of casein arc classified tinder HTS subheading 3501.10.50. Imports of casein enter the United States free of duty. The US. market for casein is served almost exclusively by imports. casein production recently began in the United States. although is not yet commercially significant. Unlike imported casein. which is produced from fresh. liquid skim milk, U.S. production of casein uses reconstituted SMP as the starting ingredient.

Biochem/physiol Actions

Partial gastrointestinal digestion of casein is a rich source of bioactive peptides, such as β-casomorphin. However, bovine casein is not homogeneous; variants A1 and B do lead to production of β-casomorphin 7 production, while A2 does not.

Downstream Products

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