90653-46-6Relevant articles and documents
Acid-labile Histidine Side-chain Protection: the N(?)-t-Butoxymethyl Group
Colombo, Roberto,Colombo, Fabio,Jones, John H.
, p. 292 - 293 (2007/10/02)
N(α)-Benzyloxycarbonyl-N(?)-t-butoxymethyl-L-histidine (1) and N(α)-fluoren-9-ylmethoxycarbonyl-N(?)-t-butoxymethyl-L-histidine (2) have been prepared and their use for the synthesis of peptides containing histidine residues has been demonstrated in two simple exercises; no difficulties were encountered, the base- and hydrogenolysis-resistant imidazole protecting group ultimately being removed by mild acidolysis.