9072-19-9

Basic information

• Product Name: Fucoidan
• Synonyms: FUCOIDAN;FUCOIDAN, FRACTION 7;FUCOIDIN;FF7;fucoidan from fucus vesiculosus;Fucoidan, Fraction 7, Fucus vesiculosus;FUCOIDAN FROM FUCUS VESICULOSUS, 9-10% S ULFUR;Fucoidin(Fucoidan)70%DerivedFromSeaweed
• CAS NO: 9072-19-9
• Molecular Formula: C7H14O7S
• Molecular Weight: 242.24686
• Product Categories: Chemical
• Mol File: 9072-19-9.mol

Chemical Properties

• Appearance: Yellow brown fine powder
• Storage Temp.: Refrigerator
• Solubility: H2O: soluble10mg/mL, clear to hazy, faintly yellow to brownish-y
• CAS DataBase Reference: Fucoidan(CAS DataBase Reference)
• NIST Chemistry Reference: Fucoidan(9072-19-9)
• EPA Substance Registry System: Fucoidan(9072-19-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 9072-19-9(Hazardous Substances Data)

Usage

Uses

Used in Food Industry:
Fucoidan is used as a thickening agent and dietary supplement for its water-soluble properties and health benefits, making fucoidan-containing food and supplements popular on the Japanese market.
Used in Pharmaceutical Industry:
Fucoidan is used as a biological response modifier and potential therapeutic agent with a wide range of biological activities. It is studied for its pharmacokinetics, safety, efficacy, and delivery methods as a potential anticancer, anti-immune, and anti-inflammatory agent.
Used in Cosmetics Industry:
Fucoidan is used as a cosmetic ingredient for its ability to be directly adsorbed by human skin, providing effects such as whitening, preserving moisture, and removing freckles.
Used in Medical Applications:
Fucoidan is used as a modulator of coagulation, an alternative to the anticoagulant heparin, and for its various biological activities such as anti-inflammation, anti-cell proliferation, anti-adhesion, and antiviral infection. It also acts as a ligand for selectins, protects gastric mucosa against proteolytic activity of gastric juice, and blocks mammalian fertilization.
Used in Anticancer Applications:
Fucoidan is used as a new anti-tumor drug or an adjuvant drug in combination with anti-tumor drugs, exerting anti-cancer effects directly through cell cycle arrest and induction of apoptosis, or indirectly by activating natural killer cells and macrophages to kill cancer cells.

Biological Activity

Fucoidan from Fucus vesiculosus is a polysaccharide composed predominantly of sulfated fucose. It has been proposed to have antitumor and antiangogenic activities in vitro. This compound it is commonly found in many of the brown Heterokontophyta algae species. It is found in the edible seaweed Undaria Pinnatifida and also found in most Fucus species.

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation which subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

in vitro

fucoidan triggered apoptosis of pc-3 cells, human prostate cancer cells, via evoking intrinsic and extrinsic signaling pathways in a dose-dependent fashion, which indicated that fucoidan could dose-dependently block the growth of pc-3 cells. the activation of apoptosis induced by fucoidan was involved in the inactivation of p38 mapk and phosphatidylinositol 3-kinase (pi3k) /akt, and the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (erk1/2 mapk) [1].

in vivo

female balb/c mice bearing breast cancer were intraperitoneally injected with fucoidan at 10 mg/kg body weight every two days for 20 days. fucoidan decreased the tumor volume and the tumor weight in balb/c mice. additionally, fucoidan triggered apoptosis, which indicated that fucoidan could exert a strong antitumor effect on breast cancer model. compared with control group, fucoidan dampened angiogenesis in tumor tissue via inducing a remarkable decrease in intratumoral vascular endothelial growth factor expression and inhibited lung metastasis of breast cancer [2].

references

[1]. boo, h., hong, j., kim, s., kang, j., kim, m., & kim, e. et al. the anticancer effect of fucoidan in pc-3 prostate cancer cells. marine drugs. 2013; 11(8): 2982-2999. [2]. xue, m., ge, y., zhang, j., wang, q., hou, l., & liu, y. et al. anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. plos one. 2012; 7(8). e43483.