91077-32-6

Basic information

• Product Name: dezinamide
• Synonyms: AN 051;AHR 11748
• CAS NO: 91077-32-6
• Molecular Formula: C₁₁H₁₁F₃N₂O₂
• Molecular Weight: 260.214
• Mol File: 91077-32-6.mol

Chemical Properties

• Boiling Point: 344.9°Cat760mmHg
• Flash Point: 162.4°C
• Appearance: /
• Density: 1.418g/cm³
• Vapor Pressure: 6.4E-05mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: dezinamide(CAS DataBase Reference)
• NIST Chemistry Reference: dezinamide(91077-32-6)
• EPA Substance Registry System: dezinamide(91077-32-6)

Safety Data

• Hazardous Substances Data: 91077-32-6(Hazardous Substances Data)

Usage

Uses

Anticonvulsant.

InChI:InChI=1/C11H11F3N2O2/c12-11(13,14)7-2-1-3-8(4-7)18-9-5-16(6-9)10(15)17/h1-4,9H,5-6H2,(H2,15,17)

Upstream product

• 76263-23-5 3-[3-(trifluoromethyl)phenoxy]azetidine 
• 556-89-8 nitrourea 
• 64-17-5 ethanol 

Relevant articles and documents

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides

A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarboxamides having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R1 and R2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R1 and R2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.

Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides

A method of treating animals to obtain muscle relaxation and/or to relieve anxiety is disclosed utilizing novel and known 3-aryloxy and 3-arylthioazetidinecarbonxamides having the formula: STR1 wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo substituted pyridyl, phenyl or substituted phenyl; R1 and R2 are hydrogen, loweralkyl, aryl, allyl groups, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloakylloweralkyl, arylloweralkyl and diloweralkylaminoalkyl, and R1 and R2 when taken together with the adjacent nitrogen atom may form a heterocyclic amine radical; R3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof and pharmaceutical salts thereof and hydrates thereof when they are possible.

3-Phenoxy-1-azetidinecarboxamides

3-Phenoxy-1-azetidinecarboxamides having the formula STR1 wherein R1 is selected from the group consisting of hydrogen, fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl or aminocarbonyl having prolonged anticonvulsant activity are discl

Process for preparing 3-phenoxy-1-azetidines and carboxamide derivatives

An improved process is disclosed for preparing 3-phenoxyazetidines which utilizes a phase transfer catalyst to add the phenoxy group to azetidine blocked in the 1-position by a diphenylmethane group and utilizes a stabilizing tertiary amine base to prevent dimerization during hydrogenolysis to remove the blocking group. The crude product containing diphenylmethane may be used without purification to prepare 3-phenoxy-1-azetidinecarboxamides.

N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides

N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides having the formula: STR1 wherein R is selected from formyl and hydroxymethyl and R1 is selected from hydrogen, fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl, N-formylcarb