76263-23-5

Basic information

• Product Name: 3-[3-(trifluoromethyl)phenoxy]azetidine
• Synonyms: 3-[3-(trifluoromethyl)phenoxy]azetidine;Azetidine, 3-[3-(trifluoroMethyl)phenoxy]-;3-(3-Trifluoromethylphenoxy)azetidine HCl;3-[3-(TRIFLUOROMETHYL)PHENOXY]AZETIDINE(WXC06309)
• CAS NO: 76263-23-5
• Molecular Formula: C₁₀H₁₀F₃NO
• Molecular Weight: 217.1877096
• EINECS: 604-604-1
• Mol File: 76263-23-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 252℃
• Flash Point: 106℃
• Appearance: /
• Density: 1.277
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-[3-(trifluoromethyl)phenoxy]azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-(trifluoromethyl)phenoxy]azetidine(76263-23-5)
• EPA Substance Registry System: 3-[3-(trifluoromethyl)phenoxy]azetidine(76263-23-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 76263-23-5(Hazardous Substances Data)

Usage

General Description

3-[3-(trifluoromethyl)phenoxy]azetidine is a chemical compound with a molecular formula C10H10F3NO. It belongs to the class of azetidines, which are heterocyclic organic compounds containing a four-membered ring with one nitrogen atom. 3-[3-(trifluoromethyl)phenoxy]azetidine is a colorless, viscous liquid at room temperature and is soluble in organic solvents. Its main applications are in the field of pharmaceuticals and agrochemicals. It is used as an intermediate in the synthesis of various drugs and pesticides due to its unique chemical properties. However, 3-[3-(trifluoromethyl)phenoxy]azetidine is known to be potentially hazardous if not handled and used properly, as it may cause skin and eye irritation and environmental harm if released into the ecosystem.

InChI:InChI=1/C10H10F3NO/c11-10(12,13)7-2-1-3-8(4-7)15-9-5-14-6-9/h1-4,9,14H,5-6H2

Downstream Products

• 106859-54-5 N-[3-(Diethylamino)propyl]-3-[3-(trifluoromethyl) phenoxy]-1-azetidinecarbothioamide, oxalate 
• 91077-32-6 3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide 
• 76263-13-3 N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide 

Relevant articles and documents

Fluorine-containing sulfonyl compound as well as intermediate, preparation method and application thereof

The invention discloses a fluorine-containing sulfonyl compound as well as an intermediate, a preparation method and application thereof. The fluorine-containing sulfonyl compound disclosed by the invention comprises positive ions and negative ions, wherein the positive ions are shown as the formula I. The fluorine-containing sulfonyl compound can react with substrates to effectively synthetize the fluorine-containing sulfonyl compound; the toxicity is low; the preparation is simple; the use is convenient; the fluorine-containing sulfonyl compound is in a solid stable state at normal temperature. In addition, the substrate applicability of the compound is extremely wide, and a phenol compound and an amine compound can be included; the fluorine-containing sulfonyl compound is a unique solidformation reagent capable of realizing the chemical conversion at present, so that important academic and application values are realized. The formula I is shown in the description.

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is -O-, -O(C1-C3 alkyl)-; -(C1-C3 alkyl)O-; -C(O)-; -C(=N-O(C1-C3 alkyl))-; -NH- or -NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, -NH(C1-C3alkyl)-; -N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is convalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid artrhritis, cancer, endometriosis and migraine.

Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents

Methods of treating cardiac arrhythmias and convulsions in warm-blooded animas and pharmaceutical compositions therefor are disclosed. The compounds useful in the methods of treatment and compositions are represented by the formula STR1 where n is 0 to 3 and R is H, C1 -C4 alkyl or arylalkyl and Ar is phenyl or substituted phenyl.