91281-33-3Relevant articles and documents
Biomimetic Oxidation of the Antimelanoma Agent 4-S-Cysteaminylphenol and Related Catechol Thioethers: Isolation and Reaction Behaviour of Novel Dihydrobenzothiazinequinones
Mascagna, Donatella,Costantini, Claudio,d'Ischia, Marco,Prota, Giuseppe
, p. 8757 - 8764 (1994)
Enzymatic and chemical oxidation of 4-S-cysteaminylphenol (1) and 4-S-cysteaminylcatechol (2) leads to the formation of the hitherto unknown dihydrobenzothiazine-6,7-quinone 4 via intramolecular cyclisation of the o-quinone 6.Oxidation of 4-S-cysteinylcat
Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of second generation prodrugs for targeted treatment of malignant melanoma
Jordan, Allan M.,Khan, Tariq H.,Malkin, Hugh,Osborn, Helen M.I.,Photiou, Andrew,Riley, Patrick A.
, p. 1549 - 1558 (2007/10/03)
Evaluation of second generation prodrugs for MDEPT, by oximetry, has highlighted structural properties that are advantageous and disadvantageous for efficient oxidation using mushroom tyrosinase. In particular, a sterically undemanding prodrug bis-(2-chlo