637-89-8

Basic information

• Product Name: 4-Mercaptophenol
• Synonyms: Phenol, 4-mercapto-;Phenol, p-mercapto-;p-Hydroxythiophenol;Thiohydroquinone;USAF B-57;usafb-57;Hydroxythiophenol,94%;4-MERCAPTOPHENOL, TECH., 90%
• CAS NO: 637-89-8
• Molecular Formula: C₆H₆OS
• Molecular Weight: 126.18
• EINECS: 211-307-6
• Product Categories: Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Miscellaneous;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiols/Mercaptans
• Mol File: 637-89-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 33-35 °C(lit.)
• Boiling Point: 149-150 °C25 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid or Low Melting Solid
• Density: 1.255
• Vapor Pressure: 0.00979mmHg at 25°C
• Refractive Index: 1.5101 (estimate)
• PKA: 6.82±0.10(Predicted)
• Water Solubility: soluble
• Sensitive: Air Sensitive
• Stability: Stability Air sensitive. Incompatible with oxidizing agents.
• BRN: 2039306
• CAS DataBase Reference: 4-Mercaptophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Mercaptophenol(637-89-8)
• EPA Substance Registry System: 4-Mercaptophenol(637-89-8)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-34-20/21/22
• Safety Statements: 26-36/37-45-36/37/39-36-7/9
• RIDADR: 2811
• WGK Germany: 3
• RTECS: MX7175000
• F: 10-13-23
• HazardClass: AIR SENSITIVE, IRRITANT-HARMFUL,
• PackingGroup: III
• Hazardous Substances Data: 637-89-8(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to light yellow solid or liquid

Uses

Different sources of media describe the Uses of 637-89-8 differently. You can refer to the following data:
1. 4-Mercaptophenol was used as a resin monomer in the study of the different gold nanocrystal core-resin shell structures.
2. 4-Mercaptophenol (MPH) has been used to study the adsorption of MPH on silver coated polystyrene nanospheres by time-dependent surface-enhanced Raman scattering (SERS) spectroscopy.4-Mercaptophenol may be used in the preparation of silylated monomer, which was employed for the synthesis of hyperbranched poly(ester-imide). 4-Mercaptophenol (H-4MP) reacts with metal tert-butoxides ([M(OBut)4]) to yield the following Group 4 phenoxy-thiols:[(HOBut)(4MP)3M(μ-4MP)]2, where M = Ti, Zr, Hf[(py)2M(4MP)], where M = Ti, Zr; py = pyridine[(py)(4MP)3Hf(μ-4MP)]2 4-Mercaptophenol may be used in the synthesis of the following:poly(ethersulfide)s via silylation followed by polycondensation with 2,6-dichloropyridine or 3,6-dichloropyridazine2,6-di-tertiarybutyl-4-mercaptophenol via Friedel-Craft′s alkylation with tert-butyl chloride in presence of a lewis acid

General Description

The density function theory calculations were performed to infer the IR and Raman spectra for 4-mercaptophenol molecule.

InChI:InChI=1/C6H6OS/c7-5-1-3-6(8)4-2-5/h1-4,7-8H/p-1

Upstream product

• 2664-63-3 4,4'-Thiodiphenol 
• 106-48-9 4-chloro-phenol 
• 108-95-2 phenol 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 7647-01-0 hydrogenchloride 
• 3774-52-5 4-thiocyanato-phenol 
• 1029438-23-0 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenethiol 
• 540-38-5 p-Iodophenol 
• 62-53-3 aniline 
• 2987-46-4 4-thiocyanatoaniline 
• 243671-62-7 (Z)-2-((p-hydroxyphenyl)thio)-1-p-toluenesulfonylethylene 
• 486449-25-6 Boc-Ala-SPhOH 
• 7664-93-9 sulfuric acid 
• 4247-67-0 3,5-dibromo-4-hydroxy-benzenesulfonyl chloride 

Downstream Products

• 70551-46-1 4-isopropyl-thiophenol 
• 30519-03-0 benzyl 4-hydroxyphenyl sulfide 
• 95309-80-1 1-benzylsulfanyl-4-benzyloxy-benzene 
• 14490-33-6 4,4'-ethanediyldimercapto-di-phenol 
• 1073-72-9 4-hydroxythioanisole 
• 636602-05-6 4-nitrobenzyl-4'-hydroxyphenylthioether 
• 143745-64-6 4-<<2-(methylamino)ethyl>thio>phenol 
• 127882-83-1 4'-O-demethyl-4β-[(4''-hydroxyphenyl)thio]-4-desoxypodophyllotoxin 
• 92210-83-8 2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenylsulfanyl)-propionic acid methyl ester 
• 107788-27-2 3-Ethoxy-4-hydroxy-5-(4-hydroxy-phenylsulfanylmethyl)-benzaldehyde 
• 125439-43-2 4-<(2-quinolinylmethyl)thio>phenol 
• 91281-33-3 2-<(4-hydroxyphenyl)thio>ethylamine hydrochloride 
• 129254-35-9 C₂₅H₂₇N₃O₉S 
• 80200-14-2 4-[2-(1-pyrazolyl)ethylthio]phenol 

Relevant articles and documents

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

A mild and selective protecting and reversed modification of thiols

One selective thiol-protecting study has been investigated for a wide range of thiols including general thiols and thiols containing multiple functional groups. The reactions of bromomaleimides and thiols under the mild condition afforded the protected products in excellent yields. The thiols can be recovered very quickly using dithiothreitol (DTT) under the mild condition.

Reductive removal of methoxyacetyl protective group using sodium borohydride

Herein, we have developed a mild and selective reductive deprotection method for the MAc protected alcohols using sodium borohydride. The new deprotection conditions provide a complete orthogonality between O-MAc and other protecting groups such as tert-butyl ester, N-Boc, Fmoc, Cbz, O-TBDMS, N-benzyl, O-benzyl, O-acetyl, N-acetyl, N-MAc, etc. In addition to O-MAc deprotection, this method is also applicable for S-MAc deprotection.