91358-96-2

Basic information

• Product Name: 4-Mercaptobenzaldehyde
• Synonyms: 4-Mercaptobenzaldehyde
• CAS NO: 91358-96-2
• Molecular Formula: C₇H₆OS
• Molecular Weight: 138.18694
• Product Categories: Aromatics;Intermediates;Aromatics, Intermediates
• Mol File: 91358-96-2.mol

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 257.061 °C at 760 mmHg
• Flash Point: 109.267 °C
• Appearance: /
• Density: 1.215 g/cm³
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMF (Slightly, Sonicated), DMSO (Very Slightly, Sonicated)
• PKA: 5.25±0.10(Predicted)
• Stability: Air and Moisture Sensitive
• CAS DataBase Reference: 4-Mercaptobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Mercaptobenzaldehyde(91358-96-2)
• EPA Substance Registry System: 4-Mercaptobenzaldehyde(91358-96-2)

Safety Data

• Hazardous Substances Data: 91358-96-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Mercaptobenzaldehyde is used as a key intermediate in the synthesis of chemopreventative agents. These agents are designed to inhibit, retard, or reverse the process of carcinogenesis, thereby reducing the risk of developing cancer. The presence of the thiol group in 4-mercaptobenzaldehyde allows for the formation of stable conjugates with other bioactive molecules, enhancing their chemopreventative potential.
Used in Analytical Chemistry:
4-Mercaptobenzaldehyde is employed in the capture of molecules for the detection of nerve agents using surface-enhanced Raman spectroscopy (SERS). This technique relies on the interaction between the target molecules and the SERS-active substrate, which in this case is 4-mercaptobenzaldehyde. The thiol group in 4-mercaptobenzaldehyde can form strong covalent bonds with metal surfaces, creating a highly sensitive platform for the detection of trace amounts of nerve agents. This application is particularly valuable in the fields of environmental monitoring, security, and defense, as it enables rapid and accurate identification of potential threats.

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 19654-38-7 N,N-dimethyl[(4-formylphenyl)thio]formamide 
• 84265-06-5 O-(4-formylphenyl) dimethylcarbamothioate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 17333-91-4 diazotiertes 4-Amino-benzaldehyd 
• 17763-69-8 4-(trifluormethanesulfonyloxy)benzaldehyde 
• 37794-15-3 p-methylsulfinylbenzaldehyde 
• 89898-72-6 4-formylphenyl thiocyanate 

Downstream Products

• 93033-60-4 (E)-4-(methylthio)benzaldehyde oxime 
• 866114-15-0 6-(4-formyl-phenylsulfanyl)-nicotinamide 
• 78832-95-8 4-(benzylmercapto)benzaldehyde 
• 1357519-07-3 4-(2-chloroallylthio)benzaldehyde 
• 1357519-13-1 4-(2-chloroallylsulfinyl)benzaldehyde 
• 3218-36-8 4-Phenylbenzaldehyde 
• 141358-18-1 4-(3-methoxyphenylthio)benzaldehyde 
• 26960-83-8 4-dodecylthiobenzaldehyde 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Relevant articles and documents

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF MEDICAL DISORDERS AND USES THEREOF

Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.

A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response and quantitative reaction towards thiols. The structural novelty of BODIPY-TS would guide the development of novel thiol probes.

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

A highly efficient transition metal-catalyzed single-step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2-ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.

Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof

The invention concerns novel substituted 1,3-diphenylprop-2-en-1-one derivatives, pharmaceutical compositions comprising same, their therapeutic uses, in particular for treating cerebral ischemia. The invention also concerns a method for preparing said derivatives.

Composition based on substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof

The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, la restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).

OPIOID RECEPTOR ANTAGONISTS

A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7.including R3', p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prev

2-Substituted and 4-substituted aryl nitrone compounds

The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.

4-fluoroalkyl-2h-benzopyrans anti-estogenic activity

This invention describes the new 4-fluoroalkyl-2H-benzopyrans of general formula I, in which Z is a straight-chain or branched-chain alkyl group with up to 5 carbon atoms that is fluorinated in at least one place, preferably a trifluoromethyl group, and R1, R2, X, Y and n have the meanings that are indicated in the description. The new compounds have at their disposal strong antiestrogenic action. In addition, they can have at their disposal estrogenic action that occurs in a tissue-selective manner. They can be used for the production of pharmaceutical agents, especially for the treatment of estrogen-dependent diseases and tumors and pharmaceutical agents for hormone replacement therapy (HRT) as well as for the prevention and treatment of osteoporosis.

Aryl monosulphides and symmetrical disulphides based second order nonlinear optical chromophores with transparency in the visible

A series of aryl monosulphides and disulphides have been synthesized and characterized. Their molecular hyperpolarizability (β) has been measured in solution with the hyper-Rayleigh Scattering technique and also calculated by semiempirical AM1 method. The trend in the observed and calculated values of first hyperpolarizability of these compounds has been found to be in good agreement. These compounds show moderate β values and excellent transparency in the visible region.

Convenient synthesis of aromatic thiols from phenols

Aromatic thiols were synthesised from phenols in good yield and under mild conditions by reaction of the corresponding triflates with sodium triisopropylsilanethiolate (NaSTIPS) and subsequent deprotection.