928118-00-7

Basic information

• Product Name: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 6-aMino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate
• CAS NO: 928118-00-7
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.296
• Mol File: 928118-00-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(928118-00-7)
• EPA Substance Registry System: 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER(928118-00-7)

Safety Data

• Hazardous Substances Data: 928118-00-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block in the synthesis of other organic compounds. Its versatile structure allows for the creation of a variety of complex organic molecules, making it a valuable component in the field of organic chemistry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a precursor in the development of new pharmaceutical drugs. Its potential biological activity and unique chemical properties make it a promising candidate for the creation of novel therapeutic agents.
Used in Scientific Research and Development:
6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER is also utilized in scientific research and development. Its chemical properties and potential applications are of interest to researchers who are exploring new methods and compounds for various applications across different industries.

Upstream product

• 28226-22-4 6-nitro-1,4-benzoxazine 
• 81721-87-1 6-nitro-4H-benzo[1,4]oxazin-3-one 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 928118-23-4 tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate 

Downstream Products

• 1202759-97-4 C₂₃H₂₃ClFN₅O₃ 

Relevant articles and documents

Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

In an effort to design inhibitors of human glutaminyl cyclase (QC), we have synthesized a library of N-aryl N-(5-methyl-1H-imidazol-1-yl)propyl thioureas and investigated the contribution of the aryl region of these compounds to their structure-activity relationships as cyclase inhibitors. Our design was guided by the proposed binding mode of the preferred substrate for the cyclase. In this series, compound 52 was identified as the most potent QC inhibitor with an IC50 value of 58 nM, which was two-fold more potent than the previously reported lead 2. Compound 52 is a most promising candidate for future evaluation to monitor its ability to reduce the formation of pGlu-Aβ and Aβ plaques in cells and transgenic animals.

Alpha2C adrenoreceptor agonists

In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.