932367-97-0Relevant articles and documents
DIHYDRO-[1H]-QUINOLIN-2-ONE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES
-
Page/Page column 32-33, (2010/11/26)
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RX
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia
Lagu, Bharat,Pio, Barbara,Lebedev, Rimma,Yang, Maria,Pelton, Patricia D.
, p. 3497 - 3503 (2008/02/09)
A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure-activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes wil