943823-22-1Relevant articles and documents
Novel azaandrostane derivatives for the synthesis of 17β-(N-tert-butyl carbamoyl)-4-aza-5α-androst-1-ene-3-one
Srinivasa Rao, Divvela V. N.,Trinadhachari, Ganala Naga,Prabahar, Koilpillai Joseph,Dandala, Ramesh,Sivakumaran, Meenakshisundaram,Naidu, Andra
, p. 663 - 667 (2008/09/18)
(Chemical Equation Presented) A new industrially viable process for the preparation of 17β-(N-tert-butyl carbamoyl)-4-aza-5α-androst-1-ene-3- one, also known by the generic name finasteride (6) from the new azaandrostane derivatives such as 17β-(N-tert-butyl carbamoyl)-4-benzoyl-4-aza-5α- androstane-3-one (4), 17β-(N-tert-butyl carbamoyl)-4-benzoyl-4-aza- 5α-androst-1-ene-3-one (5) is reported. In this process, benzoyl group is demonstrated as a novel protecting group for lactamic NH group. The structures of newly prepared compounds were established on the basis of spectral data (IR, 1H-NMR, and MS).