948571-12-8

Basic information

• Product Name: N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide
• Synonyms: N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide
• CAS NO: 948571-12-8
• Molecular Weight: 432.479
• Mol File: 948571-12-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide(948571-12-8)
• EPA Substance Registry System: N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide(948571-12-8)

Safety Data

• Hazardous Substances Data: 948571-12-8(Hazardous Substances Data)

Upstream product

• 948571-52-6 tert-butyl 2-(4-hydroxy-2-methoxyphenyl)acetate 
• 64517-88-0 1,3-dimethyl-1H-pyrazol-4-amine 
• 68500-37-8 4-chloro-7-methoxyquinoline 

Relevant articles and documents

Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases

A new series of quinoline ether inhibitors, which potently and selectively inhibit PDGFR tyrosine kinases, is described in this Letter. Compounds 23 and 33 are selective, low nanomolar inhibitors of PDGFRα and β, display good pharmacokinetics in rat and dog and are active in vivo at low doses when given orally twice daily. Further evaluation of these compounds is warranted.