64517-88-0

Basic information

• Product Name: 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE
• Synonyms: TIMTEC-BB SBB009353;ART-CHEM-BB B014444;ART-CHEM-BB B024887;AKOS PAO-0225;AKOS B014444;1,3-DIMETHYL-1H-PYRAZOL-4-AMINE;1,3-DIMETHYL-1H-PYRAZOL-4-YLAMINE;1,3-Dimethyl-4-aminopyrazole
• CAS NO: 64517-88-0
• Molecular Formula: C₅H₉N₃
• Molecular Weight: 111.15
• Product Categories: Chemical Amines;Amines;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 64517-88-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 231.5 °C at 760 mmHg
• Flash Point: 93.8 °C
• Appearance: /
• Density: 1.17 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE(64517-88-0)
• EPA Substance Registry System: 1,3-DIMETHYL-1H-PYRAZOL-4-AMINE(64517-88-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 64517-88-0(Hazardous Substances Data)

Usage

General Description

1,3-DIMETHYL-1H-PYRAZOL-4-AMINE, also known as DMPA, is a chemical compound with the molecular formula C6H9N3. It is a pyrazole derivative and is commonly used as a reagent in organic synthesis. DMPA is a white to light yellow crystalline powder that is soluble in polar solvents such as water and methanol. It is used as a building block in the production of pharmaceuticals, agrochemicals, and other organic compounds. DMPA has a wide range of applications in the chemical industry, including as a key intermediate in the synthesis of pesticides and pharmaceuticals. Additionally, it is used as a stabilizer and antioxidant in the production of polymers and plastics.

Upstream product

• 3920-38-5 1,3-dimethyl-4-nitro-1H-pyrazole 
• 74-88-4 methyl iodide 
• 5334-39-4 3-methyl-4-nitro-1H-pyrazole 
• 694-48-4 1,3-dimethyl-1H-pyrazole 

Downstream Products

• 1453848-11-7 (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1,3-dimethyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1215011-02-1 2,6-dichloro-N-(1,3-dimethyl-1H-pyrazol-4-yl)-4-(2-piperazin-1-yl-pyridin-4-yl)benzenesulfonamide 
• 1618664-02-0 4-(4-cyclobutoxy-2-((1,3-dimethyl-1H-pyrazol-4-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide 
• 1566543-01-8 1-(2-(2-(5-chloro-2-((1,3-dimethyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide 
• 1453853-28-5 (S)-1-(2-(tert-butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(( 1,3-dimethyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 
• 948571-12-8 N-(1,3-dimethyl-1H-pyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yloxy)phenyl]acetamide 

Relevant articles and documents

Alkynyl pyrimidine or alkynyl pyridine compound as well as composition and application thereof

The invention relates to alkynyl pyrimidine or alkynyl pyridine compounds represented by a formula (I) or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof. The invention also discloses a pharmaceutical composition contain

Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives

The c-jun N-terminal kinase 3 (JNK3) is expressed primarily in the brain. Numerous reports have shown that inhibition of JNK3 is a promising strategy for treatment of neurodegeneration. The optimization of aminopyrazole-based JNK3 inhibitors with improved potency, isoform selectivity, and pharmacological properties by structure-activity relationship (SAR) studies utilizing biochemical and cell-based assays, and structure-based drug design is reported. These inhibitors had high selectivity over JNK1 and p38α, minimal cytotoxicity, potent inhibition of 6-OHDA-induced mitochondrial membrane potential dissipation and ROS generation, and good drug metabolism and pharmacokinetic (DMPK) properties for iv dosing. 26n was profiled against 464 kinases and was found to be highly selective hitting only seven kinases with >80% inhibition at 10 μM. Moreover, 26n showed good solubility, good brain penetration, and good DMPK properties. Finally, the crystal structure of 26k in complex with JNK3 was solved at 1.8 ? to explore the binding mode of aminopyrazole based JNK3 inhibitors.

SYNTHESES FROM DIMETHYLPYRAZOLES I. SYNTHESIS OF NITRO- AND AMINO-SUBSTITUTED 1,3- AND 1,5-DIMETHYLPYRAZOLES

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