Welcome to LookChem.com Sign In|Join Free

CAS

  • or

949904-53-4

3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride is a benzamide derivative chemical compound featuring an 8-azabicyclo[3.2.1]octane ring system. It is a hydrochloride salt with potential pharmaceutical applications, particularly as a modulator of neurotransmitter systems in the central nervous system. Its unique structure and pharmacological properties position it as a promising candidate for the development of new drugs to treat neurological and psychiatric disorders.

949904-53-4 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

  • 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzamidehydrochloride

    Cas No: 949904-53-4

  • USD $ 1.9-2.9 / Gram

  • 100 Gram

  • 1000 Metric Ton/Month

  • Chemlyte Solutions
  • Contact Supplier
  • 949904-53-4 Structure

  • Basic information

    1. Product Name: 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride
    2. Synonyms: 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride
    3. CAS NO:949904-53-4
    4. Molecular Formula: C14H18N2O*ClH
    5. Molecular Weight: 266.76646
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 949904-53-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride(949904-53-4)
    11. EPA Substance Registry System: 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride(949904-53-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 949904-53-4(Hazardous Substances Data)

949904-53-4 Usage

Uses

Used in Pharmaceutical Industry:
3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzaMide hydrochloride is used as a potential modulator of neurotransmitter systems for the development of new drugs to treat neurological and psychiatric disorders. Its interaction with the central nervous system and structural features make it a candidate for further research and clinical studies to fully elucidate its therapeutic potential.

Check Digit Verification of cas no

The CAS Registry Mumber 949904-53-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,9,9,0 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 949904-53:
(8*9)+(7*4)+(6*9)+(5*9)+(4*0)+(3*4)+(2*5)+(1*3)=224
224 % 10 = 4
So 949904-53-4 is a valid CAS Registry Number.

949904-53-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Benzamide, 3-(3-endo)-8-azabicyclo[3.2.1]oct-3-yl-, hydrochloride

1.2 Other means of identification

Product number -
Other names 3-((1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)benzamide hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:949904-53-4 SDS

949904-53-4Relevant articles and documents

Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist

Armstrong, Scott R.,Beattie, David T.,Campbell, Christina B.,Church, Timothy J.,Colson, Pierre-Jean,Dalziel, Sean M.,Jacobsen, John R.,Jiang, Lan,Long, Daniel D.,Obedencio, Glenmar P.,Rapta, Miroslav,Saito, Daisuke,Stergiades, Ioanna,Tsuruda, Pamela R.,Van Dyke, Priscilla M.,Vickery, Ross G.

supporting information, (2019/12/11)

The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United States. Gastrointestinal dysfunction is an additional serious consequence of opioid use, and this can be treated with a localized drug distribution of a non-CNS penetrant, peripherally restricted opioid receptor antagonist. Herein, we describe the application of Theravance's multivalent approach to drug discovery coupled with a physicochemical property design strategy by which the N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenyl carboxamide series of μ-opioid receptor antagonists was optimized to afford the orally absorbed, non-CNS penetrant, Phase 3 ready clinical compound axelopran (TD-1211) 19i as a potential treatment for opioid-induced constipation.

Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

-

Page/Page column 13-14, (2009/04/24)

The invention provides heteroarylene substituted 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, A, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at th

Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

-

Page/Page column 15, (2009/04/24)

The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, and a are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opi

8-Azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

-

Page/Page column 27-28, (2008/06/13)

The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 949904-53-4