95737-68-1 Usage
A regulator of insect growth
Pyriproxyfen is a novel kind of insect growth regulator which was successfully developed by Sumitomo Chemical Industry Co., Ltd (Japan) It has the same effect on the insect as juvenile hormone and has various kinds of effects such as inhibiting the mosquitoes, pupating of the flies larvae and its feathering. Upon being exposed to this drug agent, the larvae of mosquitoes and flies will mostly die in the pupal stage without being able to get into feathering. The duration of this agent will persist up to a month or so. Moreover, it is convenient for using with no odor and is a good kind of drugs for killing of mosquito and fly.
Toxicity
Different sources of media describe the Toxicity of 95737-68-1 differently. You can refer to the following data:
1. According to our pesticide toxicity grading standards, pyriproxyfen belongs to low toxicity pesticides. The acute LD50 of rat subject to oral administration of the original drug acute is larger than 5000 mg/kg body weight. For acute percutaneous administration of rats, the LD50 is larger than 2000 mg/kg body weight. For acute inhalation of rat, the LC50 is larger than13000 mg/m3 (4h). It has slight irritation effect on eye without causing sensitization. Test dose has no mutagenic effect and teratogenic response. The non-effect dose of rats subject to 6-month of feeding study is 400mg/kg body weight. Non-effect dose of rat subject to inhalation within 28 day is 482mg/m3. It is absorbed, distributed and excreted rapidly by animal.
The above information is edited by the lookchem of Dai Xiongfeng.
2. For rat: acute oral administration: LD50> 5000mg/kg; acute percutaneous administration: LD50> 2000mg/kg.
Instructions
Pyriproxyfen can be used for controlling the larvae of mosquitoes and flies and some other pests. For prevention and control of mosquito larvae, apply 20 g of 0.5 % pyriproxyfen granules (active ingredient: 100 mg) per cubic meter directly into the water (water depth should be kept at about 10 cm which is best); for control of housefly larvae, apply 20 to 40 g of 0.5% pyriproxyfen granules (active ingredient 100~200 mg) per cubic meter for spreading on the surface of the housefly breeding ground. It has excellent inhibitory effect on the larvae of mosquitoes and flies.
Precautions
1. It should be kept in dark, cool place and kept away from fire.
2. Upon contacting with it on the skin, we should use soap and clean water for washing thoroughly.
Chemical Properties
Different sources of media describe the Chemical Properties of 95737-68-1 differently. You can refer to the following data:
1. The pure product is crystal with m.p. being 45~47 ℃, the vapor pressure being 0.29 × 10-3Pa (20 ℃), and the relative density being 1.23 (20 ℃). Solubility: xylene 50%, hexane: 40%, and methanol: 20%.
2. Gray to white crystalline solid or powder.
Also described as a pale yellow, waxy solid or liquid.
Commercial product is available as an emulsifiable concen-
trate or wettable powders.
Uses
Different sources of media describe the Uses of 95737-68-1 differently. You can refer to the following data:
1. 1. It is a kind of benzyl ethers class insect growth regulator and is a kind of juvenile hormone type inhibitor of chitin synthesis. It is characterized by its high efficiency, less medication, long duration, crop safety, low toxicity to fish, and the small impact on the ecological environment. It can be used to control Homoptera, Thysanoptera, Diptera, and Lepidoptera pests. Its inhibitory inhibition on insects is related to its influence on the molting and reproduction of insect. For mosquito class sanitation pests, applying low-dose of this product for 4th instar larvae in late phase that can result in larvae’s death at the pupation stage and inhibition of the formation of adults. For the application, apply the granules directly to the sewage pond or dispersing it in the breeding ground of mosquitoes and flies. It can also be used for prevention of sweetpotato whitefly and scale insects. Pyriproxyfen also has an inner suction transfer activity which can affect the larvae hidden in the back of the blade.
2. It is used for the control of public health pests.
2. Pyriproxyfen is a pyridine-based pesticide used against a variety of arthropoda, in particular to protect cotton crops against whitefly.
3. Pyriproxyfen is used for control of public health pests (flies,
beetles, midges, mosquitoes) by application to breeding sites.
Description
Different sources of media describe the Description of 95737-68-1 differently. You can refer to the following data:
1. Pyriproxyfen is a pyridine compound and, in common
with fenoxycarb, is a juvenile hormone mimic whose
structure is unrelated to natural juvenile hormone. It
is an insect growth regulator. Fleas absorb pyriproxyfen
either by direct contact or by ingesting blood from a
treated animal.
2. Pyriproxyfen is a pyridine insecticide that mimics juvenile growth hormone, which prevents larvae from developing into reproduction-capable adults. The LD50 of pyriproxyfen in rats is >5,000 mg/kg, >1,300 mg/cubic meter/4 hours, and >2,000 mg/kg through oral, inhalation, or percutaneous dosing, respectively. It is used as a larvicide in the drinking water of 11 municipalities in Brazil and rumors suggested it may be correlated with the increase in cases of microcephaly in Brazil. The acceptable daily intake determined by the World Health Organization is 0.3 mg/L. The prevalence of microcephaly in Brazil is not higher in municipalities that use pyriproxyfen in the water supply, compared with municipalities that use the larvicide Bti. In addition, in zebrafish, even very high doses (0.1 μg/ml, compared with 0.01 μg/ml used in practice for pest control) pyriproxyfen does not induce microcephaly or other brain malformations. Formulations containing pyriproxyfen are used for flea control in dogs and as an insecticide for ants.
Definition
ChEBI: An aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position.
Agricultural Uses
Insect growth regulator, Insecticide, Veterinary medicine: Pyriproxyfen is found in a number of household products as sprays, powders, baits, mists and shampoos for the control of fleas, ticks, mites and flying insects on pets, in the air, and in carpets and rugs. It’s a larvicidal agent that mimics juvenile insect hormone.
Trade name
ARCHER?; DALAR?; DISTANCE?; ESTEEM?; NYLAR?; S-9318?; S 31183?; SUMILARV? Pyriproxyfen
Potential Exposure
Pyriproxyfen is an unclassified insect
growth regulator, insecticide, veterinary medicine found in
a number of household products as sprays, powders, baits,
mists and shampoos for the control of fleas, ticks, mites,
and flying insects on pets, in the air, and in carpets and
rugs. It’s a l larvicidal agent that mimics juvenile insect
hormone.
Metabolic pathway
Pyriproxyfen is not persistent in soils and sediments and is rapidly
metabolised by a variety of organisms. In rats and mice, the major
metabolic pathways were hydroxylation of the aromatic ring, hydroxylation
at the 5-position of the pyridyl ring, loss of the aromatic ring,
cleavage of ether linkages and conjugation of the resultant phenols with
glucuronic or sulfuric acid. The general pathways in soils, sediments
and a variety of organisms involve fission of ether linkages and hydroxylation
of the phenoxyphenol group.
Degradation
[14C]Pyriproxyfen was dissolved in distilled water or sterile river water
at a concentration of 0.2 mg kg-1 and exposed to natural sunlight from
November to December at 40°N latitude. The DT50 values were 17.5
and 21 days in distilled water and sterile river water respectively. Photodegradation
involved cleavage at the three ether linkages and the major
products were carbon dioxide (11-29% of the applied radioactivity) and a
product formed by loss of the phenoxyphenyl group (9) (16-30%). When
[14C]pyriproxyfen was exposed to sunlight for 8 weeks on sandy loam
and silty loam soils, the DT50 values were 11 and 13 weeks respectively.
Photodegradation involved cleavage at the three ether linkages to give
products 4,6 and 10 but the major product was carbon dioxide, representing
9.5-13% of the applied radioactivity. Bound radioactivity accounted
for 11-26% of the applied radioactivity at week 8 (Miyamoto et al., 1993).
Degradation products are shown in Scheme 1.
Incompatibilities
This material is combustible. Dust may
form an explosive mixture in air. Incompatible with oxidi-
zers (chlorates, nitrates, peroxides, permanganates, perchlo-
rates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials,
strong bases, strong acids, oxoacids, epoxides.
Waste Disposal
It is the responsibility of
chemical waste generators to determine the toxicity and
physical properties and of a discarded chemical and to
properly identify its classification and certification as a hazardous waste and to determine the disposal
method. United States Environmental Protection Agency
guidelines for the classification determination are listed
in 40 CFR Parts 261.3. Additionally, waste generators
must consult and follow all regional, national, state and
local hazardous waste laws to ensure complete and
accurate classification and disposal methods. Follow
recommendations for the disposal of pesticides and
pesticide containers. Containers must be disposed
of properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office.
Check Digit Verification of cas no
The CAS Registry Mumber 95737-68-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,7,3 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 95737-68:
(7*9)+(6*5)+(5*7)+(4*3)+(3*7)+(2*6)+(1*8)=181
181 % 10 = 1
So 95737-68-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H19NO3/c1-16(23-20-9-5-6-14-21-20)15-22-17-10-12-19(13-11-17)24-18-7-3-2-4-8-18/h2-14,16H,15H2,1H3
95737-68-1Relevant articles and documents
Preparation method of pyriproxyfen
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Paragraph 0027; 0031-0034; 0037; 0038, (2021/05/01)
The invention relates to a preparation method of pyriproxyfen, which comprises the following steps: condensing 4-phenoxyphenol and propylene carbonate under the action of a catalytic amount of alkali to obtain 1-(4-phenoxyphenyl)-2-propanol PPP; and continuously condensing the obtained PPP with 2-chloropyridine to obtain pyriproxyfen. The method avoids the generation of the byproduct is-PPP in the original process, improves the product quality and yield, reduces the production cost, is simple and practical, and has a good industrial prospect.
Method for exterminating termites
-
, (2008/06/13)
A method for exterminating termites comprising using an entomopathogenic nematode together with an inset-growth regulator or a slow-acting insecticide, wherein insecticidal effects are reinforced compared with the cases using singly the entomopathogenic nematode and the insect-growth regulator or the slow-acting insecticide, respectively, and a bait station for exterminating termites that contains an entomopathogenic nematode with an insect-growth regulator or a slow-acting insecticide. According to the invention, emission of harmful chemicals to environment can be suppressed. The invention is nonpoisonous for human being and livestock, and is useful for indoor or outdoor extermination of termites.
Insecticidal compositions and methods of use employing imidacloprid and another insecticide
-
, (2008/06/13)
The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) STR1 in which R1 represents C1 -C5 -alkyl, R2 represents hydrogen or C1 -C5 -alkyl, or R1 and R2 together represent --CH2 --CH2 --; --CH2 --CH2 --CH2 -- or STR2 X represents an NH group, NCH3 group or represents sulphur, Y represents nitrogen or a CH group and Z represents cyano or nitro, with one or more of the synergists mentioned in the description.
