965-67-3

Basic information

• Product Name: Androstan-17-one, 2,3-epoxy-, (2α,3α,5α)-
• Synonyms: Androstan-17-one, 2,3-epoxy-, (2α,3α,5α)-;Androstan-17-one,2,3-epoxy-, (2a,3a,5a)-
• CAS NO: 965-67-3
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.42
• Mol File: 965-67-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Androstan-17-one, 2,3-epoxy-, (2α,3α,5α)-(CAS DataBase Reference)
• NIST Chemistry Reference: Androstan-17-one, 2,3-epoxy-, (2α,3α,5α)-(965-67-3)
• EPA Substance Registry System: Androstan-17-one, 2,3-epoxy-, (2α,3α,5α)-(965-67-3)

Safety Data

• Hazardous Substances Data: 965-67-3(Hazardous Substances Data)

Upstream product

• 91207-67-9 3α-acetoxy-2β-bromo-5α-androstan-17-one 
• 7676-27-9 3α-Bromo-5α-androstan-2β-ol-one 
• 14639-79-3 5α-androst-2-en-17-one 
• 481-29-8 Epiandrosterone 
• 10429-07-9 3β-tosyloxy-5α-androstan-17-one 
• 53-43-0 dehydroepiandrosterone 
• 19646-53-8 (3β,5α)-3-[(methylsulfonyl)oxy]androstan-17-one 

Downstream Products

• 119302-20-4 (2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol 
• 119302-24-8 (2β,3α,5α,16β,17β)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-3-hydroxy-17-acetoxyandrostane 
• 846-46-8 androstanedione 
• 4011-37-4 5α-androstane-2,17-dione 
• 1207375-03-8 3α-hydroxy-2β-phenylthioandrostan-17-one 
• 83808-48-4 2β,3α-dihydroxy-5α-androstan-17-one 
• 1207375-10-7 3α-hydroxy-2β-(2'-methoxyphenyl)thioandrostan-17-one 
• 1172999-40-4 3α-hydroxy-2β-[(phenylmethyl)amino]-5α-androstan-17-one 
• 1172999-46-0 3α-hydroxy-2β-[methyl(phenyl)amino]-5α-androstan-17-one 
• 1172999-44-8 3α-hydroxy-2β-[(3-hydroxyphenyl)amino]-5α-androstan-17-one 
• 1172999-42-6 3α-hydroxy-2β-[methyl(phenylmethyl)amino]-5α-androstan-17-one 
• 1172999-45-9 3α-hydroxy-2β-[(2-hydroxyphenyl)amino]-5α-androstan-17-one 
• 1172999-41-5 3α-hydroxy-2β-{[(4-methoxyphenyl)methyl]amino}-5α-androstan-17-one 

Relevant articles and documents

A Change from Kinetic to Thermodynamic Control Enables trans-Selective Stereochemical Editing of Vicinal Diols

Here, we report the selective, catalytic isomerization of cis-1,2-diols to trans-diequatorial-1,2-diols. The method employs triphenylsilanethiol (Ph3SiSH) as a catalyst and proceeds under mild conditions in the presence of a photoredox catalyst and under

A new and efficient method for the synthesis of rocuronium bromide

Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2β-(4-morpholinyl)-16β-(1-pyrrolidinyl)-5α-androstan-3α,17β-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove.

NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF

Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.