98777-34-5 Usage
Uses
Used in Pharmaceutical Industry:
(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique structure and stereochemistry make it a valuable intermediate in the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate is used as a versatile reactant in organic synthesis, particularly for the preparation of chiral molecules and compounds with specific biological activities. Its functional groups and stereochemistry allow for a wide range of chemical transformations and reactions, making it a useful component in the synthesis of complex organic molecules.
Used in Research and Development:
(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate is used as a research compound in the study of chiral chemistry, asymmetric synthesis, and the development of new synthetic methods. Its unique properties and reactivity make it an interesting target for chemists and researchers working in the field of organic chemistry and pharmaceutical development.
Used in the Synthesis of Antibiotics:
(2S,3S)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate is used as a reactant in the synthesis of the antibiotic Globomycin and its congener, SF-1902 A5. Its chiral structure and functional groups play a crucial role in the formation of these antibiotics, which have potential applications in the treatment of various bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 98777-34-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,7 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 98777-34:
(7*9)+(6*8)+(5*7)+(4*7)+(3*7)+(2*3)+(1*4)=205
205 % 10 = 5
So 98777-34-5 is a valid CAS Registry Number.
98777-34-5Relevant articles and documents
Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de Novo Synthesis of Pseudaminic Acid
Liu, Han,Zhang, Yanfeng,Wei, Ruohan,Andolina, Gloria,Li, Xuechen
supporting information, p. 13420 - 13428 (2017/10/05)
Pseudaminic acid (Pse) is a nonulosonic acid unique to bacterial species, found as a component of important cell surface glycans and glycoproteins in various pathogenic species, such as the critical hospital threat Pseudomonas aeruginosa. Herein we present the development of a facile and scalable de novo synthesis of Pse and its functionalized derivatives from easily available Cbz-l-allo-threonine methyl ester (16 steps in 11% yield). The key reactions in our de novo synthesis involve the diastereoselective glycine thioester isonitrile-based aldol-type reaction to create the 1,3-anti-diamino skeleton, followed by the Fukuyama reduction and the indium-mediated Barbier-type allylation. Moreover, we have studied the glycosylation of the Pse glycosyl donors and identified the structural determinants for its glycosylation diastereoselectivity, which enabled us to complete the total synthesis of P. aeruginosa 1244 pilin trisaccharide α-5NβOHC47NFmPse-(2→4)-β-Xyl-(1→3)-FucNAc.
COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
-
Paragraph 0727; 0728, (2014/08/06)
Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.
