A synthetic substance structurally analogous to histamine whose presence in minute amounts prevents or counteracts the action of excess histamine formed in body tissues. These compounds are usually complex amines of various types and also have other physiological effects and medical uses. Examples are chloropheniramine maleate, dimenhydrinate, diphenhydramine hydrochloride, imidazole, pheniramine maleate, pyrilamine maleate, thonzylamine hydrochloride, tripelennamine hydrochloride.See Antagonist, Structural.