An animal skin or hide that has been permanently combined with a tanning agent that causes a physicochemical change in the protein components of the skin. This change renders it resistant to putrefactive bacteria, enzymes, and hot water, increases its strength and abrasion resistance, and makes it serviceable for long periods of time. Tanning agents are either vegetable, mineral, or synthetic. Hides from cows or steers are chiefly used for men's shoes, transmission belting, and other heavy-duty service. These are usually vegetable-tanned. Lighter grades made from the skins of sheep, calves, or reptiles are used for shoe uppers, luggage, gloves, and similar end products (chrome-tanned). Leather is a naturally poromeric material that retains the microporosity of the original skin; this property makes it uniquely applicable to footwear; to a limited extent it is able to conform to the contour of the individual foot. Leather is made in many colors, weights, and finishes. However, it has been replaced to an increasing extent by plastics for many minor uses, and by synthetics for shoe uppers and soling.See Poromeric; Tanning.