Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists

DOI: 10.1016/j.ejmech.2017.02.060

Source and publish data:

European Journal of Medicinal Chemistry p. 433 - 439 (2017)

Update date:2022-07-29

Topics: IC50 values aryl groups pharmacokinetic properties

Authors:

O'Brien-Brown, James

Jackson, Alexander

Reekie, Tristan A.

Barron, Melissa L.

Werry, Eryn L.

Schiavini, Paolo

McDonnell, Michelle

Munoz, Lenka

Wilkinson, Shane

Noll, Benjamin

Wang, Shudong

Kassiou, Michael

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Article abstract of DOI:10.1016/j.ejmech.2017.02.060

Here we report adamantyl cyanoguanidine compounds based on hybrids of the adamantyl amide scaffold reported by AstraZeneca and cyanoguanidine scaffold reported by Abbott Laboratories. Compound 27 displayed five-fold greater inhibitory potency than the lea

Full text of DOI:10.1016/j.ejmech.2017.02.060

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